| 中国人细胞色素P4501A1基因外显子7的多态性分析 |
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| 引用本文： | 张利群,褚金花,周艳,朱章菱,邓一夫. 中国人细胞色素P4501A1基因外显子7的多态性分析[J]. 首都医科大学学报, 2002, 23(4): 323-325 |
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| 作者姓名： | 张利群 褚金花 周艳 朱章菱 邓一夫 |
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| 作者单位： | 北京军区总医院呼吸科(张利群)，首都医科大学预防医学系(褚金花)，首都医科大学附属北京朝阳医院基础医学研究中心(周艳，朱章菱)，首都医科大学预防医学系(邓一夫) |
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| 摘 要： | 为探讨中国人与吸烟致癌力有关的细胞色素P4 5 0 1A1 (cytochromeP4 5 0 1A1 ,CYP1A1 )基因催化部位 (外显子 7)的多态性分布情况 ,分析了 4 5 8例中国人CYP1A1基因外显子 7的多态性分布频率。结果显示这种多态性在男女之间没有显著差异 ,4 5 8例中国人该基因不同类型的比例分别为Ile/Ile 61 .6%、Ile/Val 2 6.4 %、Val/Val 1 2 .0 % ,其中Val/Val基因型所占的比例显著高于日本人、白种人或非洲 美国人
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| 关 键 词： | CYP1A1 基因多态性 中国人 |
| 收稿时间： | 2001-10-18 |
| 修稿时间： | 2001-10-18 |
Analysis of Polymorphism in Exon 7 of Human Cytochrome P4501A1 Gene in Chinese |
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| Zhang Liqun,Chu Jinhua,Zhou Yan,Zhu Zhangling,Deng Yifu . Analysis of Polymorphism in Exon 7 of Human Cytochrome P4501A1 Gene in Chinese[J]. Journal of Capital Medical University, 2002, 23(4): 323-325 |
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| Authors: | Zhang Liqun Chu Jinhua Zhou Yan Zhu Zhangling Deng Yifu |
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| Affiliation: | 1. Respiratory Department of Beijing Military District General Hospital;2. Department of Preventive Medicine, Capital University of Medical Sciences;3. Basic Medicine Research Centre, Beijing Chaqang Hospital, Affiliate of Capital University of Medical Sciences |
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| Abstract: | P4501A1 is a kind of enzyme related with the carcinogenic activity of aromatic hydrocarbon, the polymorphism in exons 7 of the gene could alter the function, and has been reported to be associated with lung cancer in Japanese. But data from Caucasian or African American were different. The difference is said to be from the different frequencies of this polymorphism between ethnic groups. This paper analyzed the frequency of polymorphism in exons 7 of CYP1A1 gene in Chinese by the PCR method. The results suggested that the frequencies of genotype in Chinese were Ile/Ile 61.6%, Ile/Val 26.4% and Val/Val 12.0%, no significant difference of the frequencies between male and female was found. But the frequency of Val/Val was much higher than that in Japanese, Caucasian or African American. |
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| Keywords: | CYP1A1 polymorphism Chinese |
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