| 系统性红斑狼疮患者外周血单个核细胞骨调素表达及临床意义 |
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| 引用本文： | 李龙,余学清,尹培达.系统性红斑狼疮患者外周血单个核细胞骨调素表达及临床意义[J].中华风湿病学杂志,1999,3(2):84-86. |
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| 作者姓名： | 李龙 余学清 尹培达 |
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| 作者单位： | 中山医科大学第一附属医院 |
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| 摘 要： | 目的 探讨骨调素在系统性红斑狼疮（ＳＬＥ）患者中的表达及临床意义。方法 用流式细胞仪和Ｎｏｒｔｈｅｒｎ ｂｌｏｔ杂交方法分别检测ＳＬＥ患者外周血单个核细胞（ＰＢＭＣ）ＯＰＮ蛋白和ｍｔｎＡ的表达。结果 活动期和稳定期ＳＬＥ患者ＰＢＭＣ ＯＰＮ蛋白和ｍＲＮＡ的表达均高于正常人（Ｐ〈０．０１），ＳＬＥ患者ＯＰＮ蛋白主要在淋巴细胞表达，而活动期患者ＰＢＭＣ ＯＰＮ蛋白及ｍＲＮＡ的表达高于稳定期患者（Ｐ〈０
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| 关 键 词： | 系统性红斑狼疮 骨调素 单个核细胞 病理 治疗 |
OPN expression of peripheral blood mononuclear cells in systemic lupus erythematosus (SLE)
and its clinical significance |
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| LI Long,YU Xueqing,YIN Peida,et al..OPN expression of peripheral blood mononuclear cells in systemic lupus erythematosus (SLE)
and its clinical significance[J].Chinese Journal of Rheumatology,1999,3(2):84-86. |
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| Authors: | LI Long YU Xueqing YIN Peida |
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| Institution: | LI Long,YU Xueqing,YIN Peida,et al.First Affiliated
Hospital,Sun Yatsen University of Medical Sciences,Guangzhou 510080 |
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| Abstract: | Objective To
investigate osteopontin(OPN)expression in SLE patients and its clinical significance. Methods
The OPN protein and mRNA expression in peripheral blood mononuclear cells (PBMC) from 80
patients and 30 healthy persons was detected by cytometry and Northern blot analysis method.
Results The OPN protein and mRNA expression of PBMC in SLE patients were significantly
higher than in controls (P<001).OPN protein expressin of lymphocyte was significantly higher
than that of monocyte in SLE patients.There were significant differences in PBMC protein and
mRNA expression between active group and inactive group (P<005). Conclusion OPN abnormal
expression in SLE patients suggests that OPN may play an important role in the pathogenesis
of SLE.OPN may be considered as a marker for estimating activity of SLE. |
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| Keywords: | Lupus erythematosus systemicOsteopontin |
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