Sinonasal NUT Carcinoma: Delayed Diagnosis Due to the COVID-19 Pandemic and a Review of the Literature |
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| Authors: | Francesco Maria Crocetta Cecilia Botti Martina Fornaciari Andrea Castellucci Domenico Murri Giacomo Santandrea Simonetta Piana Angelo Ghidini |
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| Affiliation: | 1.Otolaryngology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy ;2.PhD Program in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Italy ;3.Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy |
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| Abstract: | NUT carcinoma (NUT-C) is a relatively new malignancy that was recently listed in the 4th edition of the WHO Classification of Head and Neck Tumors in 2017. NUT carcinoma is a rare, aggressive, poorly differentiated carcinoma genetically defined by chromosomal rearrangement of the nuclear protein in testis (NUTM1) gene. The prognosis is extremely poor, with a mean survival < 1 year. Recent publications suggest a multimodality treatment approach. In the existing literature, only a few reports of sinonasal NUT-C have been reported. Sinonasal NUT-C is considered a very rare entity, but because of its recent inclusion as a head and neck malignancy, its true prevalence is unknown. We report the case of a 56-year-old woman with NUT-C of the sinonasal cavities. In the case reported, the coexistence of Coronavirus disease 2019 (COVID-19)-related nasal congestion delayed the diagnosis of NUT-C. Clinical presentation, diagnosis and treatment modalities are discussed together with a review of the literature. |
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| Keywords: | NUT carcinoma Nose Paranasal sinuses Nasal malignancies COVID-19 |
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