| 膀胱移行细胞癌组织中Ki-67抗原和cyclinD1的表达及其意义 |
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| 引用本文： | 瞿平 周健 唐杏. 膀胱移行细胞癌组织中Ki-67抗原和cyclinD1的表达及其意义[J]. 实用临床医学(江西), 2004, 5(3): 20-21 |
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| 作者姓名： | 瞿平 周健 唐杏 |
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| 作者单位： | 盐城市第一人民医院泌尿外科 江苏盐城224000(瞿平，周健)，盐城市第一人民医院泌尿外科 江苏盐城224000(唐杏) |
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| 摘 要： | 目的 :探讨膀胱移行细胞癌组织中Ki 6 7抗原和cyclinD1的表达及其临床意义。方法 :采用免疫组织化学SA法检测 14例正常膀胱粘膜 (正常对照组 )、4 8例膀胱移行细胞癌 (膀胱移行细胞癌组 )组织中Ki 6 7抗原和cyclinD1的表达。结果 :膀胱移行细胞癌组Ki 6 7抗原阳性率为 5 2 % ,对照组为 7.2 % ,两组比较 ,有显著性差异 (P <0 .0 5 ) ;随肿瘤病理分级增加 ,Ki 6 7抗原阳性率增加为 89.6 0 % ,cyclinD1阳性率为 5 8% ,对照组为 0 (P <0 .0 5 ) ,随肿瘤病理分级增加 ,cyclinD1阳性率降低为 11.3% ,Ki 6 7抗原与cyclinD1的表达呈负相关 (r =- 0 .38,P <0 .0 1)。结论 :Ki 6 7抗原和cyclinD1能较准确地评估膀胱移行细胞癌的生物学行为。
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| 关 键 词： | 膀胱移行细胞癌 抗原 Ki-67 cyclinD1 免疫组织化学 |
| 文章编号： | 1009-8194(2004)03-0020-02 |
| 修稿时间： | 2003-08-13 |
The Expression and Significance of Ki-67 and CyclinD1 in Transitional Cell Carcinoma of Bladder |
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| Qu Ping,Zhou Jian,Tang Xing. The Expression and Significance of Ki-67 and CyclinD1 in Transitional Cell Carcinoma of Bladder[J]. Practical Clinical Medicine, 2004, 5(3): 20-21 |
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| Authors: | Qu Ping Zhou Jian Tang Xing |
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| Abstract: | Objective:To investigate the expression and significance of Ki-67 and cyclinD 1 in transitional cell carcinoma of bladder(TCC).Methods: The expressions of Ki-67 and cyclinD 1 were examined by immunohistochemical technique in 48 cases of BTCC.Results:Expression of Ki-67 was observed in 52% of TCC and 7.2% of controls(P<0.05).The expression rate of cyclinD1 was decreased correlating with TCC stage.There was a highly significant inverse correlation between the expressions of cyclinD1 and Ki-67. Conclusion:The determination of Ki-67 and cyclinD 1 can accurately evaluate the biological behaviour of TCC. |
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| Keywords: | transitional cell carcinoma of the bladder antigens ki67 cyclinD 1 immunohistochemistry |
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