莫沙必利联合奥美拉唑治疗反流性食管炎的临床观察

目的 观察莫沙必利联合奥美拉唑治疗反流性食管炎的疗效.方法 将100例患者随机分为治疗组(50例)和对照组(50例).治疗组:奥美拉唑20mg,每日1次,莫沙必利5 mg,每13 3次口服.对照组:奥美拉唑20mg,每日1次口服.治疗前及治疗后2、4、6周计算患者症状积分.治疗后6周复查胃镜,观察胃镜下愈合率,并进行24 h食管pH监测.结果 治疗组临床有效率为100%,内镜下有效率为96%;对照组分别为88%和84%.两组比较差异有显著性(P<0.05).6周后两组pH<4反流总次数及反流总时间百分率均显著降低(P<0.05),且两组间差异有统计学意义(P<0.05).结论 莫沙必利联合奥美拉唑治疗反流性食管炎比单用奥美拉唑具有更好的疗效.

The Effect of Mosapride Combined with Omeprazole on Reflux Esophagitis

Objective To study the effect of mosapride and omeprazole on treatment of reflux esophagitis(RE).Methods 100 RE patients were randomly divided into two groups,the treatment group(50 cases):5 mg of mosapride tid,20 mg of omeprazole qd were taken orally;the control group(50 cases):20 mg omeprazole qd were taken orally.The symptoms were evaluated from pretreatment to every two weeks after the treatment.Recheck the endoscope findings at the end of 6 weeks.24-hour esophageal pH was performed in two groups.Result...