Expression patterns and prognostic value of Bag-1 and Bcl-2 in breast cancer |
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| Authors: | Yasmine Nadler Robert L Camp Jennifer M Giltnane Christopher Moeder David L Rimm Harriet M Kluger Yuval Kluger |
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| Affiliation: | (1) Department of Medicine, Yale University School of Medicine, 06520 New Haven, CT, USA;(2) Department of Pathology, Yale University School of Medicine, 06520 New Haven, CT, USA;(3) Department of Cell Biology, New York University School of Medicine, 540 First Avenue, 3rd Floor, 10016 New York, NY, USA |
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| Abstract: | Introduction Bcl-2 antanogene-1 (Bag-1) binds the anti-apoptotic mediator Bcl-2, and enhances its activity. Bcl-2 and Bag-1 are associated with chemotherapy resistance in cancer cells. Drugs that target Bcl-2 are currently in clinical development. The purpose of the present study was to examine expression patterns of Bag-1 in a large cohort of breast tumors and to assess the association with Bcl-2, estrogen receptor, progesterone receptor and Her2/neu, and other clinical/pathological variables. |
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