| 新型免疫抑制剂构效关系的研究进展 |
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| 引用本文： | 张亚,王明伟. 新型免疫抑制剂构效关系的研究进展[J]. 中国新药杂志, 2005, 14(9): 1109-1113 |
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| 作者姓名： | 张亚 王明伟 |
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| 作者单位： | 国家新药筛选中心,中国科学院上海药物研究所,上海,201203 |
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| 基金项目： | 国家科技专项基金，中国科学院知识创新工程项目 |
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| 摘 要： | 自从1986年环孢菌素首次用于控制器官移植中的免疫排斥反应以来,多种新型免疫抑制剂相继进入临床实践.与环孢菌素相比,这些新型免疫抑制药物的疗效卓著、不良反应较小.其中,他克莫司、西罗莫司、FTY720和15-脱氧精胍菌素的应用更为广泛.从作用机制、构效关系和不良反应对这几种新型免疫抑制剂在控制器官移植排斥反应研究领域的最新进展进行了较为详细的介绍.
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| 关 键 词： | 器官移植 排斥反应 免疫抑制剂 构效关系 |
| 文章编号： | 1003-3734（2005）09-1109-05 |
| 收稿时间： | 2005-03-26 |
| 修稿时间： | 2005-03-26 |
Advances in the structure-activity relationships of immunosuppressants |
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| ZHANG Ya,WANG Ming-Wei. Advances in the structure-activity relationships of immunosuppressants[J]. Chinese Journal of New Drugs, 2005, 14(9): 1109-1113 |
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| Authors: | ZHANG Ya WANG Ming-Wei |
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| Affiliation: | National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China |
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| Abstract: | Since cyclosporine was firstly used in prophylaxis and treatment of graft rejection in 1986, a number of new immunosuppressive agents, such as tacrolimus, rapamycin, FTY720 and 15-deoxyspergualin, have been introduced to clinical practices. In comparison with cyclosporine, those agents possess greater efficacies and better safe profiles. This article reviews the latest clinical outcomes regarding the management of rejection following organ transplantation by these immunosuppressants, focusing on mechanisms, structure-activity relationships and severe adverse effects |
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| Keywords: | organ transplantation rejection reactions immunosuppressant structure-activity relationships |
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