人工角膜材料分类及材料表面改性和生物相容性的研究

背景：角膜病和白内障是引起眼盲的主要原因,可以通过角膜移植的方法治愈,人工角膜的出现,使角膜移植摆脱了供体缺乏和移植成功率低的问题,为角膜盲的患者带来新的希望。 目的：利用CNKI数据库文献检索和深度分析功能,对人工角膜材料学研究及人工角膜材料分类和设计的文献资料趋势进行多层次探讨分析。 设计：文献计量学分析。 资料提取：以电子检索方式对CNKI数据库2002-01/2011-12有关人工角膜材料学研究的文献进行分析,采用检索词为“人工角膜(Artificial cornea);生物材料(Biomaterials);生物相容性(Biocompatibility);水凝胶(Hydrogel);羟基磷灰石(Hydroxyapatite,HA)等”,对检索的相关文献运用数据库中自带的分析功能和Excel软件绘制图表的功能进行分析,通过文字和图表的形式将统计和计量数据分析,描述其分布特征。 入选标准：纳入标准：①与人工角膜材料相关的基础研究论文。②与人工角膜材料临床应用相关的论文。③与人工角膜材料分类相关的研究论文。④与人工角膜材料设计相关的研究论文。排除标准：①与文章目的无关的文献。②重复研究的文献。③刊社信息。④未发表的文章。⑤需电话追踪和手工检索逐一分析的文章。⑥年鉴。 主要数据判定指标：以CNKI数据库学术期刊文献出版时间、文献数量、学科类别、研究机构、来源期刊、文献被引频次、文献下载频次、关联文献、作者分布、基金资助情况和主要关键词进行相关分析。并对CNKI数据库中博士学位论文、优秀硕士学位论文、重要会议论文和专利技术进行分析。 结果：在CNKI数据库学术期刊收录2002/2011的文献中,共检索到48篇与人工角膜材料学研究相关的文献。文献数量产出趋于平稳,最多的时间在2005年共9篇;《中国组织工程研究与临床康复》杂志发表文献量较多为9篇,占全部文献的18.8%;人工角膜材料学研究基金资助以国家自然科学基金项目为主;人工角膜材料学研究主要以水凝胶、羟基磷灰石为主,突出材料表面改性和生物相容性的研究。 结论：通过文献计量学方法对CNKI数据库关于人工角膜材料的文献进行分析,可为中国从事人工角膜材料学基础研究和临床实施的医务工作者进一步确定科研思路提供有价值的参考。 关键词：人工角膜;生物材料;生物相容性;水凝胶;羟基磷灰石;文献计量 缩略语注释：CNKI：China National Knowledge Infrastructure,中国知识基础设施工程 doi:10.3969/j.issn.1673-8225.2012.16.031

Classification,surface modification and biocompatibility of artificial cornea materials

BACKGROUND: Corneal disease and cataracts are the main reason that causes blindness, which can be cured by corneal transplantation. As the emergence of artificial cornea, make the corneal transplantation get rid of the problem in lacking of donor and transplant success rate, bring new hope for patients with corneal blindness. OBJECTIVE: Using CNKI database literature search and the depth of analysis capabilities, explore the multi-level analysis for the study of artificial cornea and artificial cornea materials classification and design of the literature data trends. DESIGN: Bibliometric data analysis. DATA RETRIEVAL: A search of related literature of artificial cornea materials research was performed in CNKI database using the key words of “Artificial cornea”, “Biomaterials”, “Biocompatibility”, “Hydrogel”, “Hydroxyapatite(HA)”, during 2002/1 to 2011/12. Using own database analysis capabilities and Excel charting functions to retrieve literature analysis, through the form of text and charts analysis the data , to describe its distribution characteristics. SELECTION CRITERIA: ①Basic research papers related to the artificial cornea materials.②Papers related to the clinical application of artificial cornea materials.③The research papers related to the classification of artificial cornea materials. ④Research papers related to the design of artificial cornea materials. Exclusion criteria: ①Literature has nothing to do with the purpose of this review. ②Duplication of research literature. ③Journal's own information. ④Unpublished papers. ⑤The article need telephone follow up to analyze and manual searches. ⑥Yearbook. MAIN OUTCOME MEASUREMENTS: In CNKI database, using academic journal articles published year, literature number, subject category, research institutions, source journals, literature citations, literature download frequency, associated literature, distribution of the author, distribution of the Funds and major keywords to analysis. RESULTS: The literature associated with academic journals in CNKI during 2002-2011, retrieved a total of 48 artificial cornea materials research literature. The number of papers was gradually increasing. Published the most in 2005, a total of 9. Journal of Clinical Rehabilitative Tissue engineering Research published literatures is 9, accounting for 18.8% of all literature. The artificial cornea materials science research funded mainly by the National Natural Science Foundation of China. The artificial cornea materials research mainly based on hydrogel and hydroxyapatite, to highlight the material surface modification and biocompatibility studies. CONCLUSION: Through the bibliometric data analysis based on CNKI database of academic journal literature of the artificial cornea materials, to provide valuable reference for Chinese medical worker in artificial cornea material science basic research and clinical practice, to further define the thinking of scientific research.