Bmi-1在结直肠癌卵巢转移患者中的表达及意义

目的探讨Bmi-1与结直肠癌临床病理因素的关系、临床意义及在卵巢转移过程中的作用。 方法对2010年4月至2011年7月间哈尔滨医科大学附属第三医院结直肠外科的44例患者病理样本进行免疫组织化学染色，检测Bmi-1蛋白在结直肠癌原发灶、正常肠黏膜及原发灶中肠源性卵巢转移癌中的表达，实验结果采用t检验或者χ2检验。 结果Bmi-1在直肠癌原发灶中表达的阳性率显著高于正常黏膜(分别为65.9%、15.9%，χ²＝22.752，P<0.01)。Bmi-1在原发灶中的高表达与结直肠癌的分化程度、分期及淋巴结转移相关(χ²＝5.116，P＝0.024；χ²＝4.856，P＝0.028；χ²＝5.495，P＝0.019)，而卵巢转移灶中的Bmi-1未见异常表达。Bmi－1高表达的患者生存期明显低于Bmi-1低表达者(13.16个月，16.87个月，t＝－2.524，P＝0.012)。 结论Bmi-1在结直肠癌原发灶中的高表达表明Bmi-1与结直肠癌的发生、发展相关。Bmi-1与伴有卵巢转移的结直肠癌患者的预后相关，可能是结直肠癌预后重要相关因子。

Expression and significance of B-cell specific moloney leukemia virus insertion site 1 in colorectal ovarian metastasis

ObjectiveThis study aims at understanding the role of Bim-1 in the clinicopathological features of colorectal cancer and the progression of ovarian metastasis. MethodsNormal intestinal mucosa, primary lesion of colorectal carcinoma and metastatic ovarian were obtained from the Third Affiliated Hospital of Harbin Medical University in April 2010 to July 2011. Immunohistochemical staining of Bmi-1 was carried out in 44 cases with colorectal carcinoma, including primary lesion the metastatic ovarian and normal intestinal mucosa.T.test or χ² test was used to statistically analysized the results. ResultsThe rate in primary lesion was significantly higher than that in normal intestinal mucosa (65.9%, 15.9%, χ²=22.752, P<0.01). Bmi-1 expression in primary lesion was significantly correlated with differentiation, TNM stage and lymphatic metastasis(χ²=5.116, P=0.024; χ²=4.856, P=0.028; χ²=5.495, P=0.019). These was no overexpressed in ovarian metastasis. Overexpression of Bmi-1 protein was significantly correlated with tumorigenesis and progression of colorectal cancer. Although Bmi-1 has no overexpression in ovarian metastasis, those patients with overexpression of Bmi-1 have a short survival (13.16 months, 16.87 months t=-2.524, P=0.012). ConclusionsOverexpression of Bmi-1 is significantly correlated with prognosis of colorectal cancer with ovarian metastasis.Bmi-1 might be regarded as an important prognostic factor of CRC.