人工血管材料生物相容性和血液相容性的研究与分析☆

背景：随着生物医学工程学和生物材料学的发展，人工血管的研究得到广泛的应用，人工血管材料得到不断更新，如何提高血管的通畅性和人工血管材料的相容性是在近年来人工血管研究的重点。 目的：利用CNKI数据库文献检索和深度分析功能，对于人工血管材料学研究的文献资料趋势进行多层次探讨分析。 设计：文献计量学分析。 资料提取：以电子检索方式对CNKI数据库2002-01/2011-12有关人工血管材料学研究的文献进行分析，采用检索词为“人工血管(Artificial blood vessels)；生物材料(Biomaterials)”，对检索的相关文献运用数据库中自带的分析功能和Excel软件绘制图表的功能进行分析，通过文字和图表的形式将统计和计量数据分析，描述其分布特征。 入选标准：纳入标准：①与人工血管材料相关的基础研究论文。②与人工血管材料临床应用相关的论文。排除标准：①与文章目的无关的文献。②重复研究的文献。③刊社信息。④未发表的文章。⑤需电话追踪和手工检索逐一分析的文章。⑥年鉴。 主要数据判定指标：以CNKI数据库学术期刊文献出版时间、文献数量、学科类别、研究机构、来源期刊、文献被引频次、文献下载频次、关联文献、作者分布、基金资助情况和主要关键词进行相关分析。并对CNKI数据库中博士学位论文、优秀硕士学位论文、专利技术和重要会议论文进行分析。 结果：在CNKI数据库学术期刊收录2002/2011的文献中，共检索到122篇与人工血管材料学研究相关的文献。文献数量产出趋于上升趋势，2008年文献产出数量最多共17篇；《中国组织工程研究与临床康复》杂志发表文献量最多为27篇，占全部文献的22.1%；人工血管材料学研究基金资助以国家自然科学基金项目为主，共发表文献30篇；人工血管材料学研究以聚氨酯的研究为主，突出材料学生物相容性和血液相容性的研究。 结论：通过文献计量学方法对CNKI数据库学术期刊关于人工血管材料的文献进行分析，可为中国从事人工血管材料学基础研究和临床实施的医务工作者进一步确定科研思路提供有价值的参考。

Biocompatibility and blood compatibility of artificial blood vessel materials

BACKGROUND: With the development of biomedical engineering and biological materials science, artificial blood vessels have been widely used. The artificial blood vessel materials are constantly updated, How to improve the patency of blood vessels and the compatibility of the artificial blood vessel materials is the focus of research in recent years. OBJECTIVE: Using CNKI database literature search and the depth of analysis capabilities, to perform the multi-level analysis for the literature data trends of artificial blood vessel materials. DESIGN: Bibliometric data analysis. DATA RETRIEVAL: A search of related literature of artificial blood vessel materials was performed in CNKI database using the key words of “Artificial blood vessels” and ”Biomaterials”, during 2002-01 to 2011-12. Database analysis capabilities and Excel charting functions were used for literature analysis, through the form of text and charts, its distribution characteristics were described. SELECTION CRITERIA: ①Basic research papers related to the artificial blood vessel materials. ②Papers related to the clinical application of artificial blood vessel materials. Exclusion criteria: ①Literature has nothing to do with the purpose of this review. ②Duplication of research literature. ③Journal's own information. ④Unpublished papers. ⑤The article need telephone follow up to analyze and manual searches. ⑥Yearbook. MAIN OUTCOME MEASUREMENTS: In CNKI database, using academic journal articles published year, literature number, subject category, research institutions, source journals, literature citations, literature download frequency, associated literature, distribution of the author, distribution of the funds and major keywords to analysis. Regarding doctoral dissertation, the outstanding master’s degree papers, conference papers and patented technology to analyze. RESULTS: The literature associated with academic journals in CNKI during 2002-2011, retrieved a total of 122 artificial blood vessel materials research literature. The number of papers was gradually increasing. Published the most in 2008, a total of 17. Journal of Clinical Rehabilitative Tissue engineering Research published literatures is 27, accounting for 22.1% of all literature. The artificial blood vessel materials science research funded mainly by the National Natural Science Foundation of China, a total of 30. The artificial blood vessel materials research mainly based on Polyurethane, to highlight materials science biocompatibility and hemocompatibility studies. CONCLUSION: Through the bibliometric data analysis based on CNKI database of academic journal literature of the artificial blood vessel materials, to provide valuable reference for Chinese medical worker in artificial blood vessel materials science basic research and clinical practice, to further define the thinking of scientific research.