一氧化氮与肌腱愈合

背景：研究表明一氧化氮在肌腱损伤愈合中发挥了重要作用。目的：综述一氧化氮与肌腱损伤愈合的相关研究进展。方法：应用计算机检索1992年1月至2011年12月 PubMed数据库相关文章，检索词为“NO，tendon，healing”，并限定文章语言种类为English。同时计算机检索1995-01/2011-12中国期刊全文数据库相关文章，检索词为“一氧化氮，肌腱，愈合”，并限定文章语言种类为中文。共检索到文献115篇，最终纳入符合标准的文献37篇。结果与结论：通常健康肌腱中不表达一氧化氮合酶，而损伤后一氧化氮合酶3种同功酶呈现高表达但表达时相不同，使用一氧化氮抑制剂会削弱肌腱的愈合，而适宜剂量的一氧化氮供体可促进肌腱愈合，其原因之一可能是一氧化氮降低了炎症反应并改善了细胞外基质代谢，从而减轻愈合期肌腱的症状和质量，提高了肌腱的功能。

Nitric oxide and tendon healing

BACKGROUND:Researches indicate nitric oxide plays a crucial role in tendon healing. OBJECTIVE:To summarize the progress of recent researches on the nitric oxide and tendon healing. METHODS:A computer-based online search of related papers from January 1992 to December 2011 was performed in PubMed database using the key words “nitric oxide, tendon, healing” in English, and in CNKI database using the key words of “nitric oxide, tendon, healing” in Chinese from January 1995 to December 2011. Totally 115 articles were found, and finally 37 articles were included in result analysis.RESULTS ADN CONCLUSION:In normal tendons, there is no expression of nitric oxide synthase; however, in injured tendons, there is a significant increase in nitric oxide synthase activity at different time. When this activity is inhibited, tendon healing is impaired. When nitric oxide, in the correct doses, is added, tendon healing is enhanced. Nitric oxide may play a role in controlling inflammation and extracellular matrix metabolism, which improves the symptoms, signs, quality and function of the tendon.