不同肥胖标准的PCOS患者可溶性细胞间粘附分子－1水平研究

【摘要】目的: 比较可溶性细胞间粘附分子－1(sICAM-1)的水平在不同肥胖标准的PCOS患者中的表达，探讨不同肥胖标准在PCOS患者中的诊治价值。方法 选取PCOS患者54例为研究对象，以体重指数（BMI）≥24kg/m2或（和）腰臀比(WHR)≥0.8为肥胖标准，将BMI≥24kg/m2的患者归为肥胖A组，BMI<24kg/m2的患者归为非肥胖A组；WHR≥0.8的患者归为肥胖B组，WHR<0.8的患者归为非肥胖B组。WHR≥0.8且BMI≥24kg/m2的患者归为肥胖C组， BMI＜24kg/m2且WHR<0.8的患者归为非肥胖C组. 比较不同组别间的血清中sICAM-1水平。结果 1.肥胖A组血清sICAM-1水平较非肥胖A组显著升高(P<0.05)；2.肥胖B组血清sICAM-1水平较非肥胖B组显著升高(P<0.05);3.肥胖C组血清sICAM-1的水平较非肥胖C组显著升高(P<0.05);4. 肥胖A、 B 、C三组之间血清sICAM-1的水平无显著差异(P>0.05)；5.非肥胖A组患者血清sICAM-1水平高于非肥胖B组、C组患者(P<0.05)；而非肥胖B组与非肥胖C组血清sICAM-1的水平无显著差异 (P>0.05);6. 血清sICAM-1水平与BMI、WHR均呈正相关(P<0.05)，sICAM-1与WHR的相关性大于sICAM-1与BMI的相关性。结论 本研究表明PCOS患者血清sICAM-1水平与肥胖相关， WHR≥0.8的中心性肥胖对sICAM-1影响更大。提示：PCOS中心性肥胖患者可能更容易出现心血管疾病。控制WHR能减少sICAM-1的表达,延缓心血管疾病的发生发展。

ADHESION MOLECULE-1 IN DIFFERENT OBESITY STANDARD WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

【Abstract】 Objective To compare the level of soluble intercellular adhesion molecule-1(sICAM-1) in different obesity standard women with polycystic ovary syndrome (PCOS), approaching the value of treatment and diagnose of different obesity standard in PCOS. Methods Selected 54 women with PCOS for experimental group, According to BMI≥24kg/m2 or（and）WHR≥0.8, all the subjects were respectively divided into obese A subgroup （BMI≥24kg/m2）、obese B subgroup（WHR≥0.8）、obese C subgroup （WHR≥0.8 and BMI≥24kg/m2）and non-obese A subgroup（BMI<24kg/m2）、non-obese B subgroup（WHR<0.8） 、non-obese C subgroup（BMI＜24kg/m2 and WHR＜0.8）.Then compared the level of sICAM-1 between different obese subgroup and non-obese subgroup. Results 1.Serum sICAM-1 level in obese A subgroup was higher than non-obese A subgroup (P<0.05);2. Serum sICAM-1 level in obese B subgroup was higher than non-obese B subgroup (P<0.05);3. Serum sICAM-1 level in obese C subgroup was higher than non-obese C subgroup (P<0.05); 4. There was no significant deviation in serum sICAM-1 level between the patients with obese A subgroup and obese B subgroup and obese C subgroup (P>0.05);5. Serum sICAM-1 level in non-obese A subgroup was higher than non-obese B subgroup and non-obese C subgroup (P<0.05); There was no significant deviation in serum sICAM-1 level between the patients with non-obese B subgroup and non-obese C subgroup (P>0.05); 6. Serum sICAM-1 level had positive correlation with BMI,WHR(P<0.05),the dependablity between Serum sICAM-1 level and WHR exceeded the dependability between Serum sICAM-1 level and BMI. Conclusion Our study showed that the serum sICAM-1 level of PCOS patients is correlated to obesity, the affection of WHR ≥0.8 central obesity in sICAM-1 is even bigger, To hint: PCOS patients with central obesity possible to appear cardiovascular diseases. So we must control WHR to decrease the expression of sICAM-1, in order to prevent cardiovascular diseases.