同种异体骨移植后T淋巴细胞的分布与变化

背景：研究表明体液免疫在同种异体骨移植免疫排斥反应中不起主要作用,目前一般认为细胞免疫在排斥反应中起主导作用。 目的：概述同种异体骨移植后T淋巴细胞的分布与变化。 方法：采用电子检索的方式,在万方数据库(http://www.wanfangdata.com.cn/)、Pubmed数据库(http:// www.ncbi.nlm.nih.gov.pubmed/)中检索1990-01/2011-12关于同种异体骨移植后T淋巴细胞的分布与变化的文章,关键词为“骨移植,同种异体,T淋巴细胞”。排除重复研究、普通综述或Meta分析类文章,筛选纳入31篇文献进行评价。 结果与结论：同种异体骨移植后,体内抑制T淋巴细胞被激活,对免疫排斥反应起负反馈调节作用,T淋巴细胞发生显著变化;但深低温冷冻、冷冻干燥、γ射线辐照、复合免疫抑制剂等方法可以有效降低其免疫原性及疾病传播的风险。大量研究认为,同种异体骨具有骨组织的完整性结构、机械稳定性、生物学活性、骨诱导能力和极低的免疫性以及与宿主骨有较强的愈合能力等优点,植入体内后通过全方位再血管化、新骨形成、异体骨与宿主骨连接而实现生物学骨掺入过程。提示同种异体骨是一种可行的移植材料,可作为目前修复骨缺损的重要手段之一。 

Distribution and changes of T lymphocytes after allogeneic bone grafting

BACKGROUND: Studies have shown that humoral immunity cannot afford a major role in allograft immune rejection. It is generally believed that cellular immune rejection plays a leading role in the rejection. OBJECTIVE: To outline the changes and distribution of T lymphocytes after allogeneic bone grafting. METHODS: An electronic search of Wanfang and PubMed databases (1990-01/2011-12) was performed for articles addressing the changes and distribution of T lymphocytes after allogeneic bone grafting using the key words of “bone graft, allograft, T lymphocytes”. Repetitive articles, reviews and Meta analysis were excluded, and finally 31 articles were included in result analysis. RESULTS AND CONCLUSION: After allogeneic bone graft, activated T lymphocytes in vivo play a role in negative feedback regulation of immune rejections, and T lymphocytes experience a dramatic change. However, deep cryopreservation, freeze-drying, γ-ray irradiation, and immunosuppressive agents can effectively reduce the immunogenicity and disease transmission. A great amount of studies have demonstrated that the allogeneic bone has intact structure of bone tissues, mechanical stability, biological activity, bone induction capacity, low immunity and strong healing capacity with the host bone. After implantation, the allogeneic bone can achieve the bone incorporation through the vascularization, new bone formation, and connection with the host bone. It is indicated that the allogeneic bone as a feasible graft material, can be considered as an important method for bone defect repair.