造血干细胞移植治疗地中海贫血

背景：造血干细胞移植是目前根治地中海贫血的最佳方法，造血干细胞移植包括骨髓移植、脐血移植、宫内造血干细胞移植、外周血造血干细胞移植。目的：利用SCI数据库文献检索和深度分析功能，对造血干细胞移植的研究文献进行多层次探讨分析。方法：以“造血干细胞(hematopoietic stem cell or HSC)；移植(transplantation)；地中海贫血(thalassaemia or thalassemia)；β型地中海贫血(beta thalassaemia or beta thalassemia or β thalassaemia or β thalassemia)”为关键词，检索SCI数据库2002-01/2011-12的相关文献，并将分析结果及资料导出，以文字和图表的形式进行统计和计量分析，描述其分布特征。纳入标准：检索与造血干细胞移植治疗地中海贫血相关的文献。文献类型包括：①研究原著。②会议摘要。③综述。④会议文章。⑤快报。⑥编辑素材。⑦勘误。⑧章节。⑨新闻。排除标准：①与文章目的无关的文献。②大于10年较陈旧的文献。③未发表的文章。结果与结论：SCI数据库2002/2011共检索到8 981篇造血干细胞移植相关的文献，研究原著以4 922篇位居首位，其中有7篇可以确定为经典文献，文献数量在2002/2011呈总体上升趋势，Blood《血液》杂志发表文献量最多， 1 515篇，占全部文献的16.87%。通过文献计量学方法对来源于SCI数据库关于造血干细胞移植的文献进行分析，可为了解该领域的现状、趋势和研究者进一步确定热点难点提供有价值的参考。

Transplantation of hematopoietic stem cells for treatment of thalassemia

BACKGROUND:Hematopoietic stem cell transplantation is the best way to cure thalassemia, including bone marrow transplant, umbilical cord blood transplantation, intrauterine hematopoietic stem cell transplantation, peripheral blood stem cell transplantation.OBJECTIVE:To multivariately analyze the literature on the hematopoietic stem cell transplantation for thalassemia through Science Citation Index database and its analysis tool.METHODS:A computer-based retrieval was performed for the literature of hematopoietic stem cell transplantation for treatment of thalassemia with the key words hematopoietic stem cell, transplantation, thalassaemia or thalassemia, beta thalassaemia or beta thalassemia or β thalassaemia or β thalassemia published between January 2002 and December 2011 in SCI database. The retrieval results were analyzed, and the trends were described in words and graphics. Articles on the hematopoietic stem cell transplantation for thalassemia including the following types: (1) peer-reviewed original papers; (2) meeting abstracts; (3) proceedings papers; (4) reviews; (5) letters; (6) editorial materials; (7) corrections; (8) book chapter; (9) news items. Exclusive criteria included (1) articles unrelated to hematopoietic stem cell transplantation for thalassemia; (2) articles published before 2002; (3) articles which were not published on journals.RESULTS AND CONCLUSION:A total of 8 981 literatures on the hematopoietic stem cell transplantation for thalassemia were retrieved in SCI database, most of which were published as original articles. Seven articles were identified as classic literature. The overall number of literature had an upward trend from 2002 to 2011. Blood published most papers in this field (n=1515, 16.87%). This paper provides a valuable reference for researchers to understand the overview and present situation of this field in order to set further research.