老年髋部骨折患者尿脱氧吡啶啉与肌酐比值及Singh指数的相关性

背景：尿脱氧吡啶啉与肌酐比值与Singh指数是临床常用的评估骨强度和骨量丢失情况的指标,但二者之间的相关性分析鲜有报道。目的：观察脱氧吡啶啉与肌酐比值与Singh指数在老年髋部骨折中的相关性。方法：对100例60岁以上新鲜股骨颈骨折或股骨转子间骨折患者测定尿脱氧吡啶啉、尿肌酐及股骨近端Singh指数,计算脱氧吡啶啉与肌酐比值与Singh指数的关系。结果与结论：100例股骨颈骨折或股骨转子间骨折患者尿脱氧吡啶啉与肌酐比值为(6.11±2.09) nmol/mmol;其中97例高于正常值范围,提示这些患者已经有骨量的丢失;Singh指数4级以下91例;5级9例。Spearman相关性分析结果显示,老年髋部骨折患者尿脱氧吡啶啉与肌酐比值与Singh指数呈负相关(r=-0.32,P=0.007)。提示脱氧吡啶啉与肌酐比值与Singh指数存在线性相关性,在评价老年髋部骨折患者骨质方面2种方法结果一致。

Relationship between deoxypyridinoline/creatinine and Singh index in elderly hip fracture patients

BACKGROUND:The deoxypyridinoline and creatinine ratio (DPD/Cr) and Singh index are widely used in measuring bone strength and bone lost in clinic, but the relationship between them is rarely reported.OBJECTIVE:To analyze the relationship between DPD/Cr and Singh index in elderly hip fracture patients.METHODS:A total of 100 samples over the age of 60 were collected from patients suffered fresh femoral neck fracture and intertrochanteric fracture. The deoxypyridinoline, urinary creatinine and Singh index were measured, and the relationship between DPD/Cr and Singh index was calculated.RESULTS AND CONCLUSION:The DPD/Cr of 100 patients that suffered fresh femoral neck fracture and intertrochanteric fracture was (6.11±2.09) nmol/mmol; among them, 97 cases were higher than normal, and the other 3 cases were normal. The Singh index showed below grade IV in 91 cases, grade V in 9 cases. Spearman correlation analysis showed that the DPD/Cr in elderly hip fracture was negatively correlated with Singh index (r=-0.32, P=0.007). There was liner correlation between DPD/Cr and Singh index, the DPD/Cr and Singh index were consistent in the evaluation of bone quality.