人工食管替代物中组织工程化食管的研究与分析

背景：应用组织工程技术构建有活性的人工食管，为食管缺损的修复提供一条崭新的道路，组织工程食管研究目前已取得令人鼓舞的进展。目的：利用CNKI数据库、SCI数据库文献检索和深度分析功能，对于组织工程食管的文献资料趋势进行多层次探讨分析，根据检索文献结果分析组织工程食管的未来发展趋势。方法：通过计算机检索CNKI数据库、SCI数据库2002/2011有关组织工程食管的文献，检索词为“食管(esophagus)，组织工程(tissue engineering)，食管上皮细胞(esophageal epithelial cells)，支架构建(scaffold construction)”，分析结果以文字和图表的形式进行统计和计量分析，描述其分布特征。结果与结论：①CNKI数据库及SCI数据库2002-01/2011-12收录组织工程食管相关文献均不多，中国在该领域的文献产出量逐渐增多，总体呈上升趋势，《中国组织工程研究与临床康复》杂志发表此范畴文献量最多。②组织工程食管研究文献得到基金项目仅有10项。美国在该领域文献产出量多于其他国家，对该领域研究起到重要作用，发表文献较多的机构集中在奥地利格拉茨医科大学、新加坡南洋理工大学、美国华盛顿大学。③通过文献计量学方法对来源于国内外数据库关于组织工程食管的文献进行多层面的数据分析。

The research and analysis of tissue-engineered esophagus in artificial esophagus substitutes

BACKGROUND:Tissue engineering construction technology provides a new approach for esophageal defect repair.OBJECTIVE:According to the literature retrieval results, to multivariately analyze the literatures on tissue-engineered esophagus through China National Knowledge Infrastructure (CNKI) database and Science Citation Index (SCI) database and to explore the future development tendency of tissue-engineered esophagus.METHODS:A retrieval was performed for the literature of tissue-engineered esophagus, using the key words of “esophagus, tissue engineering, esophageal epithelial cells, scaffold construction” between January 2002 and December 2011 in CNKI database and SCI database. The retrieval results were analyzed, and the trends were described in words and graphics.RESULTS AND CONCLUSION:(1)The literature of tissue-engineered esophagus between January 2002 and December 2011 was not too much. The overall number of literature had an upward trend from 2002 to 2011. (2)Journal of Clinical Rehabilitative Tissue Engineering Research published most papers in this field. There were 10 fund projects on the tissue-engineered esophagus. United States published more literature than other countries, which play an important role in the field of the tissue-engineered esophagus. Many of literatures were published from Medical University of Graz, Nanyang Technological University, and University of Washington. (3)This paper provides a valuable reference for researchers to understand the overview and present situation of this field.