镍铬合金材料与口腔软组织的生物相容性

Biocompatibility of Ni-Cr alloy materials and oral soft tissue

BACKGROUND: Ni-Cr alloy ceramic materials are accepted by the majority of patients due to the low prices, and more than 50% of patients choose the Ni-Cr alloy porcelain teeth. Due to the materials persisting in the electrolyte environment, precipitation of nickel ions can cause allergy in some patients. How to improve the biological safety of Ni-Cr alloy materials arises more attention.OBJECTIVE: Using CNKI database literature search and the depth of analysis capabilities, to explore the literature data trends in the study of biocompatibility of Ni-Cr alloy materials and oral soft tissue.DESIGN: Bibliometric data analysis.DATA RETRIEVAL: A search of related literature of biocompatibility of Ni-Cr alloy materials and oral soft tissue was performed in CNKI database using the key words of “Ni-Cr alloy”, “biomaterials” and “biocompatibility”, during 2002-01 to 2011-12. Own database analysis capabilities and Excel charting functions were used to retrieve literature analysis; through the form of text and charts, the data were analyzed to describe the distribution characteristics.SELECTION CRITERIA: Inclusive criteria: ①Basic research papers related to Ni-Cr alloy materials. ②Papers related to the clinical application of Ni-Cr alloy materials. ③Research papers related to biocompatibility of Ni-Cr alloy materials. Exclusive criteria: ①Literature has nothing to do with the purpose of this review. ②Duplication of research literature. ③Journal’s own information. ④Unpublished papers. ⑤The article need telephone follow up to analyze and manual searches. ⑥Year book.MAIN OUTCOME MEASUREMENTS: In CNKI database, academic journal articles published year, literature number, subject category, research institutions, source journals, literature citations, literature download frequency, associated literature, distribution of the author, distribution of the fund and major keywords were analyzed, the Ph.D. thesis, outstanding master's degree papers, conference papers, patented technology, biocompatibility of Ni-Cr alloy materials and oral soft tissue research literature were analyzed. RESULTS: A total of 107 research literatures related to biocompatibility of Ni-Cr alloy materials and oral soft tissue were retrieved in CNKI during 2002-2011. The number of papers was gradually increased. Most literatures were published in 2007 (n=18). Journal of Clinical Rehabilitative Tissue Engineering Research published eight literatures, accounting for 7.5% of all literature. A total of 14 foundation projects mainly belonged to the Provincial Science and Technology Foundations. The frequently used key words were Ni-Cr alloy, Ni-Cr alloy porcelain crown and porcelain crown. From the analysis result of key words, the comparative studies between metal ceramic and Ni-Cr alloy porcelain accounted for the majority. Main researches were based on the effect of Ni-Cr alloy on the periodontal tissue. CONCLUSION: Through the bibliometric data analysis on biocompatibility of Ni-Cr alloy materials and oral soft tissue in CNKI database, we can provide valuable reference for Chinese medical worker in Ni-Cr alloy basic research and prosthodontics.