造血干细胞移植治疗恶性血液病的研究与分析

背景：近年来，随着血液学及相关领域基础和临床研究的不断发展，造血干细胞移植已成为治疗恶性血液病的有效手段，甚至是治愈某些血液病的惟一方法。 目的：对造血干细胞移植治疗恶性血液病SCI数据库文献资料进行多层次对比分析。 方法：通过计算机检索SCI数据库2001/2010有关造血干细胞移植治疗恶性血液病的文献，检索词为“造血干细胞(hematopoietic stem cell)，移植(transplantation)，急性髓性白血病(acute myelogenous leukemia)，非霍奇金淋巴瘤(non-hodgkin lymphoma)，慢性髓细胞白血病(chronic myelocytic leukemia)”，分析结果以文字和图表的形式进行统计和计量学分析。 结果与结论：SCI数据库2001/2010收录造血干细胞移植治疗恶性血液病相关文献中美国在该领域文献产出量多于其他国家，对该领域研究有重要贡献，发表文献较多的机构集中在美国Fred Hutchinson癌症研究中心。10年来文献数量呈总体上升趋势。

Hematopoietic stem cell transplantation for treating hematological malignancies

BACKGROUND:In recent years, with the continuous development of hematology and related fields of basic and clinical research, hematopoietic stem cell transplantation has become an effective means of treatment for hematologic malignancies, or even the only way to cure certain blood diseases. OBJECTIVE:According to the literature retrieval results, to comparatively analyze the literatures on the hematopoietic stem cell transplantation for treating hematological malignancies in SCI database and to explore the future development tendency of hematopoietic stem cell transplantation for treating hematological malignancies. METHODS:A retrieval was performed for the literature of the hematopoietic stem cell transplantation for treating hematological malignancies, using key words of “hematopoietic stem cell, transplantation, acute myelogenous leukemia, non-hodgkin lymphoma, chronic myelocytic leukemia” between 2001-01 and 2010-12 in SCI database. The retrieval results were analyzed, and the trends were described in words and graphics. RESULTS AND CONCLUSION:The overall literatures of the hematopoietic stem cell transplantation for treating hematological malignancies had an upward trend from 2001 to 2010. United States published more literature than other countries, which play an important role in the field of the hematopoietic stem cell transplantation for treating hematological malignancies. Most of literatures were published from Fred Hutchinson Cancer Research Center. This paper provides a valuable reference for researchers to understand the overview and present situation of this field.