骨形态发生蛋白-α-氰基丙烯酸复合生物胶修复大鼠下颌骨骨缺损的研究 |
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作者姓名: | 王 新 谢富强 张 贇 孙 健 |
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作者单位: | 1兰州大学口腔医学院甘肃省兰州市 730000
2兰州大学第二医院口腔科,甘肃省兰州市 730030 |
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摘 要: | 背景:骨形态发生蛋白2是骨形态蛋白家族中诱导成骨作用最强,并能单独诱导成骨的因子。
目的:观察骨形态发生蛋白-α-氰基丙烯酸正丁酯复合生物胶修复大鼠下颌骨缺损的效果。
方法:将54只Wistar大鼠随机分为实验组、对照组、空白对照组。3组均制作下颌骨缺损模型,实验组缺损处植入骨形态发生蛋白-α-氰基丙烯酸复合生物胶,对照组植入壳聚糖温敏性凝胶,空白对照组不植入任何材料。
结果与结论:①X射线片检查:植入后3,6,9 周时,实验组剩余骨缺损面积均低于对照组及空白对照组(P < 0.05)。②组织学观察:病理切片显示,实验组下颌骨成骨情况优于对照组及空白对照组。表明骨形态发生蛋白-α-氰基丙烯酸复合生物胶具有良好的生物相容性和骨诱导性,可显著促进颌骨缺损修复。
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关 键 词: | 骨形态发生蛋白2 α-氰基丙烯酸酯生物胶 壳聚糖 下颌骨缺损 修复 |
收稿时间: | 2012-01-14 |
Compound bone morphogenetic protein-alpha-cyanoacrylate biological glue repairs mandibular defects in rats |
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Authors: | Wang Xin Xie Fu-qiang Zhang Yun Sun Jian |
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Institution: | 1School of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China
2Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China |
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Abstract: | BACKGROUND:Bone morphogenetic protein 2 is the strongest in the family of bone morphogenetic proteins which can induce osteogenesis separately.
OBJECTIVE:To evaluate the effectiveness and feasibility of implantation of the compound bone morphogenetic protein- cyanoacrylate biological glue in the reconstruction of rat mandibular defects.
METHODS:Totally 54 male Wistar rats were divided into three groups randomly and equally: The experimental group, the control group (the chitosan group) and the blank group. Mandibular defects of rats were repairing by implanting the compound bone morphogenetic protein-α-cyanoacrylate biological glue in the experimental group. While mandibular defects of the chitosan group were repaired only with chitosan. The blank group received no implantation.
RESULTS AND CONCLUSION:①X-ray examination: At weeks 3, 6, 9 postoperation, the area of residual mandibular defects in the experimental group was smaller than that of the other two groups. There was a statistically significant difference between the experimental and the other two groups (P < 0.05). ②Histopathology observation: The new bone mass in the experimental group was superior to those in the other two groups. It is demonstrated bone morphogenetic protein α-cyanoacrylate biological glue can be used to restoration of rat mandibular bone defects and significantly promote the mandibular repair. |
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