医用生物蛋白胶在颌下腺手术中的应用：随机对照

背景：医用生物蛋白胶具有预防渗液、渗血、组织粘连及促进伤口愈合等作用。 目的：评价医用生物蛋白胶在颌下腺手术中应用的临床效果。 方法：将58例颌下腺切除患者随机分成实验组(n=28)和对照组(n=30)。颌下腺切除后给予止血,实验组向创面喷洒医用生物蛋白胶,对照组创面不喷洒医用生物蛋白胶。 结果与结论：实验组生物蛋白胶喷洒后5~10 s内形成胶冻样物,3~5 min完全凝固,凝胶附着在创面,无不良反应及肝肾功能异常。实验组总引流量及第1天引流量少于对照组(P < 0.05),术后拔管时间及切口拆线时间短于对照组(P < 0.05),瘢痕粘连情况轻于对照组,且患者自觉症状优于对照组。说明医用生物蛋白胶具有封闭手术创面、止血、促进愈合的作用,应用在颌下腺手术中安全、有效、可靠。关键词：医用生物蛋白胶;颌下腺切除;止血;总引流量;生物材料临床试验 doi:10.3969/j.issn.1673-8225.2012.16.038

Application of biomedical fibrin glue in submandibular gland surgery: Randomized controlled study

BACKGROUND: Biomedical fibrin glue can prevent wound effusion, exudation and adhesion, as well as promote wound healing. OBJECTIVE: To evaluate the clinical effects of biomedical fibrin glue in submandibular gland surgery. METHODS: Fifty-eight cases of submandibular gland excision were randomly divided into experimental group (n=28) and control group (n=30). Biomedical fibrin glue was applied in the operative wound of the experimental group after hemostasis, while the control group was not treated with biomedical fibrin glue. RESULTS AND CONCLUSION: Biomedical fibrin glue formed a jelly-like material after spraying within 5-10 seconds in the experimental group, and solidified completely in 3-5 minutes. The gel was attached to the wound surface and there were no adverse reactions and dysfunctions in the liver and kidney. The total drainage flow and the drainage flow on the first postoperative day of the experimental group were lower than those of the control group (P < 0.05), as well as the extubation time and time for stitches removal were shorter than those of the control group (P < 0.05). Besides, patients with subjective symptoms and scar adhesion formation in the experimental group were better than those in the control group. These findings suggest that biomedical fibrin glue is safe, effective and reliable in submandibular gland surgery for blocking operative wound surface, hemostasis and promoting healing.