人工髋关节置换后假体松动原因分析

背景：人工髋关节置换已被广泛开展，假体无菌性松动是人工关节置换后的常见并发症，亦是造成人工髋关节置换失败的重要原因之一，假体松动的原因与多种因素有关。 目的：对人工髋关节置换后假体松动的原因进行分析，比较国内外研究文献的发展趋势进行多层次探讨分析。 方法：从人工髋关节置换后的磨损颗粒和相关细胞因子的角度分析与假体松动的相关性，并对中国CNKI数据库学术期刊和Web of Science数据库2002年至2011年收录有关人工髋关节置换后假体松动研究的文献进行分析，运用数据库的分析功能和Excel软件图表的功能分析数据特征。 结果与结论：人工髋关节置换后假体的无菌性松动与关节磨损颗粒、细胞因子、生物力学、患者自身因素、术中操作和术后指导等相关因素有关。CNKI数据库2002年至2011年共收录66篇与人工髋关节置换后假体松动研究相关的文献，Web of Science数据库共收录891篇相关文献，文献数量均处于逐渐上升的发展趋势。国内相关文献的发表数量、被引频次等方面与国外有较大差距。《骨与关节外科杂志：美国卷》是人工髋关节置换后假体松动研究的核心杂志。了解导致人工髋关节置换后假体松动的原因，可以更好指导临床医生预防假体松动的发生，提高患者术后的生活质量。

Reason analysis on prosthesis loosening after artificial hip arthroplasty

BACKGROUND:Artificial hip arthroplasty has been widely used, aseptic loosening of the prosthesis is a common complication after artificial joint arthroplasty, and it is one of the important reasons for the failure of artificial hip arthroplasty. The prosthesis loosening is correlated with a variety of factors. OBJECTIVE:To analyze the reason of prosthesis loosening after artificial hip arthroplasty, and to compare and multi-level analyze the trends of domestic and foreign researches and literatures. METHODS:The correlation between artificial hip arthroplasty and prosthesis loosening was analyzed from the aspects of wear particles and related cytokines, and the articles on the prosthesis loosening after artificial hip arthroplasty were searched from the CNKI database and Web of Science database from 2002 to 2011 and analyzed. The characteristics of the data were analyzed by the analysis capabilities of the database and chart function of Excel software. RESULTS AND CONCLUSION:The aseptic prosthesis loosening after artificial hip arthroplasty is correlated with wear particles, cytokines, biomechanics, the patient's own factors, intraoperative operation, post-operative instructions and other relevant factors. A total of 66 articles on the prosthesis loosening after artificial hip arthroplasty were screened out from the CNKI database from 2002 to 2011, and 891 articles were screened out from Web of Science database, and the number of the articles is in the increasing trend. There is great difference of the number and the cited frequency between the domestic articles and foreign articles. Bone and Joint Surgery: American Volume is the core magazine of the prosthesis loosening after artificial hip arthroplasty. Understanding the reasons for prosthesis loosening after artificial hip arthroplasty can guide the clinicians to prevent the occurrence of prosthesis loosening and improve the quality of life of patients.