复合骨形态发生蛋白缓释材料修复兔桡骨缺损

背景：在聚乳酸-聚羟基乙酸中加入β-磷酸三钙可调控其降解速率和强度，加载骨形态发生蛋白可增强材料的诱导成骨能力。 目的：检验β-磷酸三钙/聚乳酸-聚羟基乙酸/异烟肼/骨形态发生蛋白缓释材料修复兔桡骨节段性骨缺损的效果。 方法：制作兔左侧桡骨12 mm缺损模型，随机分4组，分别于骨缺损处植入β-磷酸三钙/聚乳酸-聚羟基乙酸材料、β-磷酸三钙/聚乳酸-聚羟基乙酸/异烟肼缓释材料、β-磷酸三钙/聚乳酸-聚羟基乙酸/异烟肼/骨形态发生蛋白缓释材料，并设置空白对照组(不植入任何材料)。 结果与结论：术后12周时，β-磷酸三钙/聚乳酸-聚羟基乙酸材料组、β-磷酸三钙/聚乳酸-聚羟基乙酸/异烟肼缓释材料组、β-磷酸三钙/聚乳酸-聚羟基乙酸/异烟肼/骨形态发生蛋白缓释组骨缺损都得到较好修复，其中β-磷酸三钙/聚乳酸-聚羟基乙酸/异烟肼/骨形态发生蛋白缓释组骨缺损修复效果最佳(P < 0.05)，空白对照组骨缺损未修复。表明β-磷酸三钙/聚乳酸-聚羟基乙酸/异烟肼/骨形态发生蛋白缓释材料可很好修复兔节段性骨缺损。

Bone morphogenic protein slow-release compound materials for repair of radial defects in rabbits

BACKGROUND:The degradation rate and strength of poly (lactic-co-glycolic acid) (PLGA) can be regulated by the addition of β-tricalcium phosphate (TCP), and the load of bone morphogenetic protein (BMP) can promote the osteoinductive capacity. OBJECTIVE:To test the effect of slow-release PLGA/β-TCP/isoniazid (INH)/BMP material on the repair of segmental radial defects in rabbits. METHODS: Forty New Zealand rabbits were collected and a rabbit model of 12-mm left radial defects was established. The rabbits were randomly divided into four groups: group 1, group 2, group 3 and group 4. The former three groups were implanted PLGA/β-TCP material, PLGA/β-TCP/INH material and PLGA/β-TCP/INH / BMP material, respectively. The group 4 served as the blank control group (without implants). RESULTS AND CONCLUSION:At week 12 after treatment, radial defects in the former three groups were all repaired well, and the PLGA/β-TCP/INH /BMP group obtained the best results (P < 0.05). The blank control group failed to restore radial defects. These results suggest that the slow-release PLGA/β-TCP/INH/BMP material can effectively repair the 12-mm long radial defects in rabbits.