FDG PET imaging in hereditary thyroid cancer |
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Authors: | A Bor S Szakll Jr I Klein M Ksler B Vincze L Trn M G
dny H Herzog I Pter O sik |
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Institution: | Department of Head and Neck Surgery, National Institute of Oncology, Budapest, Hungary. |
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Abstract: | AIM: To report the role of different imaging methods in staging individuals with multiple endocrine neoplasia 2A (MEN2A) or familial medullary thyroid carcinoma (FMTC). MATERIAL AND METHODS: Fourteen newly diagnosed gene carriers underwent cervical ultrasound scanning (US), cervical and mediastinal CT, MRI and whole-body meta-131I]iodobenzylguanidine (MIBG) scintigraphy and 18F]fluorodeoxyglucose (FDG) PET scanning. RESULTS: US identified seven true primary cancer. CT and MRI located only tumors > or =5 mm in diameter. MIBG scintigraphy and FDG PET could not identify MTC foci within the thyroid. Whole-body FDG PET identified two true-positive and one false-positive lymph node metastases. MIBG scintigraphy did not identify lymph node metastases. Total thyroidectomy was performed in 12 cases, and subtotal thyroidectomy in two subjects. CONCLUSIONS: Whole-body FDG PET and cervical US help stage individuals carrying mutant genes verifying MEN2A or FMTC. |
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Keywords: | familial medullary thyroid carcinoma multiple endocrine neoplasia type 2 RET proto-oncogene thyroidectomy positron emission tomography ultrasonography |
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