| 全反式维甲酸对结肠癌不同增殖潜能细胞株增殖的抑制作用研究 |
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| 引用本文： | 殷 平,李 才,于建渤,安锦丹,宋 学. 全反式维甲酸对结肠癌不同增殖潜能细胞株增殖的抑制作用研究[J]. 中国肿瘤生物治疗杂志, 2004, 11(3): 175-178 |
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| 作者姓名： | 殷 平 李 才 于建渤 安锦丹 宋 学 |
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| 作者单位： | 1. 牡丹江医学院病理教研室,黑龙江,157011
2. 吉林大学再生医学科学研究所病理研究室,长春,130021 |
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| 摘 要： | 目的:研究ATRA对结肠癌不同增殖能力细胞株生长抑制的可能机制,为ATRA应用于结肠癌的治疗提供可靠依据.方法:应用细胞观察、FACS和MTT方法,研究ATRA对结肠癌不同增殖能力细胞株LS174T和CW-2细胞的生长抑制现象.结果:LS174T的生长速度明显比CW-2细胞快.ATRA对体外培养的结肠癌细胞株LS174T和CW-2细胞的生长有明显抑制和诱导细胞分化作用.结论:ATRA对LS174T和CW-2细胞的生长有抑制作用,抑制细胞增殖的程度与ATRA的浓度有关,ATRA对结肠癌细胞有一定的抑制癌细胞增殖和诱导癌细胞分化作用.
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| 关 键 词： | 结肠肿瘤 全反式维甲酸 细胞周期 |
| 文章编号： | 1007-385X(2004)03-0175-04 |
| 收稿时间： | 2003-10-23 |
| 修稿时间： | 2003-10-23 |
The Inhibition on the Proliferation of Colorectal Carcinoma Cell Strain with Different Proliferative Potential by All Trans Retinoic Acid |
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| YIN Ping,LI Cai,YU Jian-bo,AN Jin-dan and SONG Xue. The Inhibition on the Proliferation of Colorectal Carcinoma Cell Strain with Different Proliferative Potential by All Trans Retinoic Acid[J]. Chinses Journal of Cancer Biotherapy, 2004, 11(3): 175-178 |
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| Authors: | YIN Ping LI Cai YU Jian-bo AN Jin-dan SONG Xue |
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| Affiliation: | Department of Pathology, Mu Danjiang Medical College, Hei Longjiang 157011, China;Pathological Laboratory Regeneration Institude of Jinlin University, Changchun 130021, China;Department of Pathology, Mu Danjiang Medical College, Hei Longjiang 157011, China;Department of Pathology, Mu Danjiang Medical College, Hei Longjiang 157011, China;Department of Pathology, Mu Danjiang Medical College, Hei Longjiang 157011, China |
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| Abstract: | Objective: The inhibition on the proliferation of colorectal carcinoma cell strain with different proliferative potential by ATRA was investigated in present study, which would benefit for the therapy of ATRA on colorectal carcinoma. Methods: The proliferation of LS174T and CW-2 colorectal carcinoma cell strain inhibited by ATRA was determined using cell observation, FACS and MTT methods. Results: The growth speed of LS174T cell strain was faster than that of CW-2. ATRA played a significant role on inhibiting the proliferation of LS174T and CW-2 cell strain and inducting the cell differetiation in vitro. Conclusions: ATRA could inhibit the growth of LS174T and CW-2 cell strain. ATRA could inhibit the proliferation of colorectal carcinoma cell and induce cell differentiation to some extent, which was correlated with the concentration of ATRA. |
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| Keywords: | colorectal carcinoma all-trans retinoic acid cell cycle |
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