妊高征患者胎盘绒毛细胞色素C氧化酶活性的变化

为探讨线粒体能量代谢细胞色素C氧化酶活性在妊高征发病机制中的作用。应用紫外分光光度法测定了32例妊高征患者(妊高征组)和26例正常妊娠妇女(对照组)的胎盘绒毛细胞色素C氧化酶的活性。结果发现患者平均年龄在妊高征组(27．23±3．78)岁]与对照组(26．87±3．70)岁]间差异无显著性(P>0．05)，孕周以妊高征组(37．30±2．96)周]为低，与对照组(38．91±1.70)周]间差异有显著性(P<0．05)。妊高征组细胞色素C氧化酶活性明显低于对照组细胞色素C氧化速率常数分别为(0．30±0．39)／min和(0．73±0．54)／min，P<0．01]。妊高征组中IUGR的发生率显著高于对照组(P<0．05)。提示细胞色素C氧化酶活性降低可以影响电子传递链的功能，引起ATP生成减少，线粒体能量代谢障碍，从而可能导致妊高征发病及胎盘功能障碍。

Changes of Activity of Placental Villus Cytochrome C Oxidase in Pregnant Women with Preeclampsia

To explore the role of cytochrome C oxidase (CCO) in the pathogenesis of preeclampsiais, CCO activity was determined in 32 patients with preeclampsia and 26 normotension pregnancy women by the rate of cyanide-sensitive oxidation of reduced cytochrome c using ultraviolet spectrophotometry. The results showed that CCO activity was significantly lower in the preeclampsia group (0. 30±0. 39/min, n=32) than in the control group (0. 73±0. 54/min, n=26), P＜0. 01. The occurrence of IUGR in the preeclampsia group was significantly higher than in the control group (P＜0. 05). It was suggested that the decrease of activity of CCO might interfere with the function of electronic chains, result in the reduction of ATP production, leading to the mitochondria dysfunction and placental dysfunction in preeclampsia patients. Mitochondria dysfunction may be involved in the pathogenesis of preeclampsia.