Sequence-based HLA-A,B, C,DP, DQ,and DR typing of 159 individuals from the Worcester region of the Western Cape province of South Africa |
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| Authors: | Alba Grifoni John Sidney Chelsea Carpenter Elizabeth Phillips Simon Mallal Thomas J Scriba Alessandro Sette Cecilia S Lindestam Arlehamn |
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| Institution: | 1. Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA;2. Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia 6150, Australia;3. Vanderbilt University School of Medicine, Nashville, TN 37235, USA;4. South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa;5. Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA |
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| Abstract: | DNA sequence-based typing at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci was performed on samples provided by 159 individuals from the Worcester region of the Western Cape province of South Africa. The purpose of the study was to characterize allele frequencies in the local population, to support studies of T cell immunity against pathogens, including Mycobacterium tuberculosis. There are no detectable deviations from Hardy Weinberg proportions for the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, and -DRB1 loci. A minor deviation was detected at the HLA-DQB1 locus due to an excess of homozygotes. The genotype data are available in the Allele Frequencies Net Database under identifier 3425. |
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| Keywords: | HLA alleles HLA typing South Africa Western Cape Worcester |
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