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Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells |
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| Authors: | Joseph R. Leventhal Joshua Miller James M. Mathew Sunil Kurian Anat R. Tambur John Friedewald Jane Charrette Michael M. Abecassis |
| Affiliation: | 1. Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, USA;2. Department of Microbiology-Immunology, Northwestern University, Chicago, IL, USA;3. Department of Molecular and Experimental Medicine, The Scripps Research Institute and Scripps Center for Organ Transplantation, La Jolla, CA, USA;4. Division of Nephrology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA |
| Abstract: | Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5?year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4+CD25HighCD127?FOXP3+) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned. |
| Keywords: | Tolerance HLA-identical renal transplants T and B regulatory cells Genomic markers |
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