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Association between KIR genes and dust mite sensitization in a Brazilian population
Authors:Marcela Caleffi da Costa Lima Caniatti  Sueli Donizete Borelli  Ana Lúcia Falavigna Guilherme  Soraya Barrionuevo Franzener  Luiza Tamie Tsuneto
Affiliation:Department of Basic Health Sciences, Universidade Estadual de Maringá (UEM), Maringá, Paraná, Brazil
Abstract:

Background

Killer cell immunoglobulin-like receptors (KIRs), found on the surface of natural killer (NK) cells, play a key role in controlling the innate response. Such response depends on a series of cellular interactions between these receptors and HLA activating/inhibiting ligands. Atopic diseases have been associated with genes that regulate cytokine production and HLA genes, which may either protect or predispose to hypersensitivity.

Objective

To verify an association study of KIR genes with sensitization to the following mites: Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Blomia tropicalis.

Methods

A total of 341 children aged up to 14?years, were classified as mite-sensitive or mite-insensitive after undergoing a skin prick test for immediate allergic reactions. The presence/absence of KIR genes and their human leukocyte antigen (HLA) ligands was determined by polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) with the commercial kit LabType? using Luminex?.

Results

The frequencies of KIR genes and their respective class I HLA ligands and the frequency of haplotypes were performed in sensitive and insensitive individuals, and no significant differences were found.

Conclusion

Our results suggest no influence of KIR genes on resistance/susceptibility to sensitization to dust mites.
Keywords:IgE  Immunoglobulin E  HLA  Human Leukocyte Antigen  KIR  Killer Cell Immunoglobulin-like Receptor  NK  Natural killer cells  PCR-SSO  Polymerase Chain Reaction-Sequence Specific Oligonucleotide  SD  OR  Chi-square Test  NCRs  Natural Cytotoxicity Receptors  SAPE  R-phycoerythrin conjugate  Mites  KIR receptors  HLA antigens  Genetic association studies  Genetic heterogeneity
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