HLA-G and vertical mother-to-child transmission of human papillomavirus infection |
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Authors: | Karolina Louvanto Michel Roger Marie-Claude Faucher Kari Syrjänen Seija Grenman Stina Syrjänen |
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Affiliation: | 1. Department of Obstetrics and Gynaecology, Turku University Hospital, University of Turku, Kiinanmyllynkatu 13, 20520 Turku, Finland;2. Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK;3. Department of Oral Pathology and Radiology, University of Turku, Lemminkäisenkatu 2, 20520 Turku, Finland;4. Centre de Recherche du CHUM et Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, 2900, boul. Édouard-Montpetit, Montréal H3T 1J4, Canada;5. Department of Clinical Research, Biohit Oyj, Laippatie 1, 00880 Helsinki, Finland;6. Department of Pathology, Turku University Hospital, Kiinanmyllynkatu 10, 20520 Turku, Finland |
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Abstract: | Role of host factors in transmission of human papillomavirus (HPV)-infection from mother to her offspring is not known. Our aim was to study whether human leukocyte antigen (HLA)-G allele concordance among the mother–child pairs could facilitate vertical transmission of HPV, because HLA-G may contribute to immune tolerance in pregnancy. Altogether, 310 mother-child pairs were included from the Finnish Family HPV study. Overall, nine different HLA-G alleles were identified. The HLA-G genotype concordance of G101:01:01/01:04:01 increased the risk of high risk (HR)-HPV genotype positivity in cord blood and infant’s oral mucosa. The mother-child concordance of G101:01:02/01:01:02 increased the risk of oral HPV positivity with HR-HPV genotypes both in the mother and offspring; OR 2.45 (95%CI 1.24–4.85). Discordant HLA-G allele for G101:04:01 and for G101:06 was significantly associated with infant’s oral low risk (LR)-HPV at birth, OR 3.07 (95%CI 1.01–9.36) and OR 5.19 (95%CI 1.22–22.03), respectively. HLA-G had no association with HPV genotype-specific concordance between the mother and child at birth nor influence on perinatal HPV status of the child. Taken together, our results show that HLA-G molecules have a role in predicting the newborn’s likelihood for oral HPV infection at birth. |
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Keywords: | HPV human papillomavirus HLA human leukocyte antigen STI sexually transmitted infection HR high-risk LR low-risk FFHPV cohort Finnish Family HPV cohort PCR polymerase chain reaction CMI cell-mediated immune HLA-G Human papillomavirus Vertical transmission Mother Newborn |
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