介入再通术改善慢性闭塞性脑血管病变患者认知功能的初步研究

目的 观察介入再通术对慢性闭塞性脑血管病变(chronic total cerebrovascular occlusion,CTO)患者认知功能的改善情况,并与未进行血管再通的CTO患者进行对比.方法 选择我院2013年5月至2016年5月收治的CTO患者55例,其中介入再通组(治疗组)21例,非再通组(对照组)34例,比较术后12、24个月认知功能情况,采用简易智能精神状态检查量表(mini-mental state examination,MMSE)、蒙特利尔认知功能评分表(Montreal cognitive assessment,MoCA)评估患者认知功能.结果 治疗组与对照组患者术前美国国立卫生研究院卒中评分量表(national institute of health stroke scale,NIHSS)评分差异有统计学意义(P＜0.05),而性别、年龄、文化程度、脑血管危险因素、认知功能等基线资料差异没有统计学意义(P＞0.05).随访期间,两组患者认知功能(12个月后MMSE、MoCA,24个月后MMSE、MoCA量表评分)比较差异有统计学意义(P ＜0.05,P＜0.01).结论 介入再通术可以明显改善CTO患者的认知功能.

Interventional recanalization improves cognitive function in patients with chronic total cerebrovascular occlusion

Objective To investigate the efficacy of interventional recanalization in cognitive function in the patients with chronic total cerebrovascular occlusion (CTO).Methods Fifty-five patients with CTO admitted in our hospital from May 2013 to May 2016 were analyzed retrospectively,involving 21 recanalization patients as the treatment group and 34 non-recanalization patients as the control group.Mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) were used to investigate the cognitive function in the first and second years after recanalization.Results There was difference in the national institute of health stroke scale (NIHSS) score between the treatment and control groups (4.80 ± 3.76 vs 2.71 ±2.92,P ＜ 0.05),while there was no significant difference in baseline data including gender,age,culture level,cerebrovascular risk factors and cognitive function (P ＞ 0.05).In the follow-up period,there were significant differences in the cognitive function between the former and latter groups in MMSE,MoCA in the first year,and MMSE,and MoCA in the second year (P ＜ 0.05,P ＜ 0.01).Conclusion The interventional recanalization can significantly improve cognitive function of the patients with CTO.