| 线粒体DNA突变和肿瘤发生 |
| |
| 引用本文： | 赵乐,陈葳,李旭.线粒体DNA突变和肿瘤发生[J].中国妇幼健康研究,2003,14(6):428-430. |
| |
| 作者姓名： | 赵乐 陈葳 李旭 |
| |
| 作者单位： | 西安交通大学第一医院实验医学中心,陕西,西安,710061 |
| |
| 摘 要： | 肿瘤细胞线粒体及线粒体DNA的研究已从形态学改变进展至分子水平的变化。由于近年来在多种肿瘤组织中发现了线粒体DNA的突变 ,而且线粒体DNA的突变率明显高于核基因 ,所以研究者们趋向认为线粒体DNA的突变与肿瘤发生密切相关。我们就近年来线粒体DNA突变与肿瘤关系的研究进展做一综述 ,以期探讨线粒体DNA突变在肿瘤发生中的作用
|
| 关 键 词： | 线粒体DNA 突变 肿瘤 |
| 文章编号： | 1008-2514(2003)06-428-3 |
| 修稿时间： | 2003年10月6日 |
Correlation between mutations of mitochondrial DNA and tumorigenesis |
| |
| ZHAO Le,CHEN Wei,LI Xu.Correlation between mutations of mitochondrial DNA and tumorigenesis[J].Chinese Journal of Maternal and Child Health Research,2003,14(6):428-430. |
| |
| Authors: | ZHAO Le CHEN Wei LI Xu |
| |
| Abstract: | The research on mitochondrion and mitochondrial DNA in tumor cells has developed from morphological changes to molecular alterations. Because mitochondrial DNA mutations are present in many kinds of tumors and its mutation rate is significantly higher than that of nuclear DNA, researchers have a tendency to think that mitochondrial DNA mutations are closely related to the occurrence of tumor. In this article, we reviewed the development in research on the correlation between mutations of mtDNA and tumorigenesis to investigate the roles of mitochondrial DNA mutations in tumorigenesis. |
| |
| Keywords: | mitochondrial DNA mutation tumor |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
