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Association of Interferon-Gamma Gene Polymorphisms in Taiwanese Children with Biliary Atresia |
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| Authors: | Hung-Chang Lee Tzu-Yang Chang Chun-Yan Yeung Wai-Tao Chan Chuen-Bin Jiang Wei-Fang Chen Hui-Wen Chan Hsin-Fu Liu Marie Lin Yann-Jinn Lee |
| Affiliation: | 1. Departments of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan 3. Department of Pediatrics, Taipei Medical University, Taipei, Taiwan 2. Medical Research, Mackay Memorial Hospital, Taipei, Taiwan 4. Mackay Medicine, Nursing and Management College, Taipei, Taiwan 5. Departments of Pediatrics and Medical Research, Mackay Memorial Hospital, 45, Min-Sheng Rd, Tamshui, 25115, Taipei County, Taiwan |
| Abstract: | BackgroundBiliary atresia (BA) is a devastating neonatal hepatobiliary disease characterized by bile duct inflammation and fibrosis. The pathogenesis remains unclear, but immunologically mediated injury to bile ducts following an infectious insult is likely to play a critical role. Interferon-gamma (IFN-γ) is a key cytokine that affects immune-mediated inflammatory responses.ObjectiveThis study aims to investigate whether polymorphisms of the IFN-γ (IFNG) gene were associated with susceptibility to BA.MethodsThe IFNG ?1615 C/T, ?183 G/T, +874 A/T, and +2197 A/G polymorphisms were genotyped using the TaqMan assay, and CA repeat microsatellite was analyzed using capillary electrophoresis in 50 children with BA and 788 ethnically matched healthy controls.ResultsThe distribution of genotype, allele, and haplotype frequencies of these IFNG gene variants did not differ significantly between children with BA and controls.ConclusionPolymorphisms of the IFNG gene do not appear to play a major role in the genetic predisposition to BA in Taiwanese children. |
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