应用近红外漫反射光谱法对红霉素薄膜衣片进行一致性检验

目的：应用近红外漫反射光谱法对红霉素薄膜衣片进行一致性检验。方法：使用矢量归一化对某厂家红霉素薄膜衣片进行预处理，建立一致性检验方法。结果：确定Conformity Index（CI）为3，使用一致性检验方法可以显著区分与某厂家样本主成分相同的其他厂家样本。结论：本方法快速简便，结果准确，适用于药品质量在线监控和假劣药品的快速筛查。

Conformity Test of Erythromycin Film-coated Tablets by Near Infrared Diffuse Reflectance Spectroscopy

Objective： To eslablish the near infrared diffuse reflectance spectroscopy method to perform conformity test of erythromycin film-coated tablets. Method： Erythromycin film-coated tablets from different manufacturers were collected and measured to establish conformity test by vector normalization（SNV） for spectra data pretreatment. Result： Samples with the same principal component of different manufacturers were significant different by conformity test while conformity test was set to 3. Conclusion： Conformity test method is simple, rapid and accurate. It can be implemented in medicine quality control on-line and fast screening of counterfeit drug.