维持性血液透析患者HCV抗体阳转随访研究

目的了解某院维持性血液透析患者丙型肝炎病毒(HCV)抗体阳转情况。方法2010年3月-2011年5月，对该院门诊和(或)病房进行持续性血液透析治疗，时间≥1个月的75例患者进行随访研究，随访时间为14个月。分为初始抗 HCV阴性组（组1）:2010年3月进入观察的32例患者；新入抗 HCV阴性组（组2）:之后陆续进入观察的43例患者。比较两组血液透析患者HCV感染情况。结果75例维持性血液透析患者HCV阳性率为6.67%（5/75）,组1新发阳性率为9.38%（3/32），组2新发阳性率为4.65%（2/43），两组比较，差异无统计学意义（χ2=0.645，P=0.361）。两组血液透析患者总抗 HCV年阳转率为8.25%。结论该院维持性血液透析患者抗 HCV年阳转率较高，需加强管理和防控。

A follow up study on seroconversion to anti HCV positive in maintenance hemodialysis patients

Objective To observe the sequential prevalence rate of anti-HCV and the rate of seroconversion to an- ti-HCV positive for a year in maintenance hemodialysis （HD）patients, and evaluate the effect of prevention and con- trol measures. Methods From March 2010 to May 2011, 75 patients who received HD in a hospital for at least one month were followed up for 14 months. Patients were divided into 2 groups, group 1：32 patients were under observation from March 2010; group 2：43 patients were under observation subsequently. HCV infection in two groups were compared. Results The positive rate of HCV in 75 patients was 6. 67%（5/75）. The positive in group 1 and group 2 was 9. 38 % （3/32） and 4. 65% （2/43） respectively, there was no significant difference between two groups （X2 = 0. 645, P〉0. 361）. The yearly seroconversion rate to anti-HCV positive of two groups was 8. 25%. Conclusion HCV seroconversion rate in HD patients in this hospital is high, strict control and prevention measures for HCV- infected patients are of great importance for the prevention of HCV transmission among hemodialysis patients.