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ROLES OF SOME INFLAMMATORY MEDIATORS IN THE PATHOGENESIS OF EARLY PULMONARY EDEMA IN STEAM RESPIRATORY BURNS
Authors:A Li  K Y Jiang  Z C Yang  P F Zhu  W H Huang  S Z Zhou  Y L Dong  Y J Liang  Y H Huang  D F Yao
Abstract:The roles of some inflammatory mediators in the pathogenesis of early pulmonary edema by steam inhalation were studied. The experiments were carried out on 36 healthy dogs. The results showed that the pathogenesis of pulmonary edema in severe steam respiratory burns is mainly as follows: direct action by heat leads to organic lesions of pulmonary capillaries and the changes of some inflammatary mediators, i.e., complements, anaphylatoxin, his- tamine, PGFi and cAMP, in the left ventricular blood and the lung tissues resulting in increase of per- meability of pulmonary capillaries.
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