Involvement of gamma-amino butyric acid (GABA) in the anticonvulsant action of methaqualone |
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Authors: | S R Naik P R Naik U K Sheth |
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Institution: | (1) Pharmacology Research Unit, Council of Scientific and Industrial Research, Department of Pharmacology, Seth G. S. Medical College, Parel, 400 012 Bombay, India |
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Abstract: | The effects of methaqualone on isonicotinic acid hydrazide, 6-mercapto propionic acid, picrotoxin, and strychnine-induced convulsion were studied in mice and the results compared with diazepam. Methaqualone, like diazepam, was found to be a selective antagonist of isoniazid-induced convulsion and a much less effective inhibitor of strychnine convulsion.Methaqualone elicits muscle-relaxant, sedative, and anticonvulsant effects at different dose levels. At low, nonsedative doses the drug produces anticonvulsant effects, and at higher doses, muscle-relaxant and sedative effects. It appears that the mechanism(s) of action of methaqualone is on GABA deficiency or receptor blockade, rather than on glycine receptors. |
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Keywords: | Isonicotinic acid hydrazide 6-Mercapto propionic acid Picrotoxin strychnine Convulsion GABA |
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