| 血浆中降钙素基因相关肽与糖尿病大鼠早期肾损害的相关性研究 |
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| 引用本文： | 孟德欣,杨笑宇,贾秀月,李翠玲.血浆中降钙素基因相关肽与糖尿病大鼠早期肾损害的相关性研究[J].黑龙江医药科学,2002,25(5):20-20. |
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| 作者姓名： | 孟德欣 杨笑宇 贾秀月 李翠玲 |
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| 作者单位： | 1. 佳木斯大学基础医学院生理教研室
2. 佳本斯大学第二附属医院佳木斯,154007 |
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| 摘 要： | 目的：观察糖尿病大鼠血浆中CGRP的含量变化与24h尿微量白蛋白的关系，为早期防治DN提供理论依据。方法：Wistar大鼠，体重160-200g，于造成糖尿病大鼠模型后第6、8、10、12、14周测定血浆中的CGRP和24h尿微量白蛋白。结果：血浆中的CGRP在造模后第6周无明显改变，第8周开始呈进行性下降，并与24h尿微量白蛋白呈显著负相关，结论：动物观察血浆中CGRP的变化对于DN的早期发现及分析病情有重要意义。
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| 关 键 词： | 血浆 降钙素基因相关肽 糖尿病 糖尿病肾病 DM DN 动物模型 相关性 |
| 文章编号： | 1008-0104(2002)05-0020-01 |
| 修稿时间： | 2002年8月30日 |
Relationship between serum CGRP and early kidney damage in diabetic rats |
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| MENG Dexin,YANG Xiaoyu,JIA Xiuyue,LI Cuiling.Relationship between serum CGRP and early kidney damage in diabetic rats[J].Heilongjiang Medicine and Pharmacy,2002,25(5):20-20. |
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| Authors: | MENG Dexin YANG Xiaoyu JIA Xiuyue LI Cuiling |
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| Institution: | MENG Dexin1 YANG Xiaoyu2 JIA Xiuyue1 LI Cuiling1 |
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| Abstract: | Objective: To provide theoretical basis for preventing early injury of kidney, we observed the relationship between the alteration in serum CGRP in diabetic rats and the quantity of uric micro-albumin in 24h. Methods: Wistar rats, weight 160~200g, were assayed for the serum CGRP content in diabetic rats and the quantity of uric micro-albumin in 24h at the 6th,8th,10th,12th and 14th weeks after they were made the model of diabetic rats. Results: The CGRP content in serum in diabetic rats did not obviously alter at the 6th week but it evidently declined at the 8th week and related with the quantity of uric micro-albumin in 24h. Conclusion: The alteration in serum CGRP in diabetic rats is significant in early discovering and analyzing DN. |
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| Keywords: | CGRP DM DN |
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