| 肾细胞癌组织中b-FGF的表达与肿瘤微血管密度的关系 |
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| 引用本文： | 车乐,杨学辉,朱积川,王晓峰,侯树坤. 肾细胞癌组织中b-FGF的表达与肿瘤微血管密度的关系[J]. 肿瘤防治研究, 2002, 29(2): 114-115 |
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| 作者姓名： | 车乐 杨学辉 朱积川 王晓峰 侯树坤 |
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| 作者单位： | 1. 100700,北京军区总医院泌尿外科
2. 北京大学人民医院 |
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| 摘 要： | 目的 探讨b FGF(碱性成纤维细胞生长因子 )在肾癌微血管形成中的作用及与肾癌生物学特性的关系。方法 采用免疫组化技术测定 3 5例肾癌患者癌组织和癌旁正常肾组织b FGF表达和MVD(肿瘤微血管密度)。结果 肾癌组织中b FGF表达明显高于癌旁和周围正常肾组织 (P <0 .0 1 )。b FGF表达升高与肿瘤分期、分级密切相关 ,肾细胞癌组织中MVD与b FGF表达呈明显正相关。结论 b FGF是肾细胞癌组织中重要的血管生长因子之一 ,b FGF表达和MVD与肾细胞癌的预后有关。
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| 关 键 词： | 肾癌 碱性成纤维细胞生长因子 肿瘤微血管密度 免疫组化 |
| 文章编号： | 1000-8578(2002)02-0114-02 |
| 收稿时间： | 2001-03-25 |
| 修稿时间： | 2001-03-31 |
Relation of expression of b-FGF in renal cell carcinoma and MVD |
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| BAO Le|qun,PENG Yi|mei,ZHANG Xin|hua,et,al. Relation of expression of b-FGF in renal cell carcinoma and MVD[J]. Cancer Research on Prevention and Treatment, 2002, 29(2): 114-115 |
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| Authors: | BAO Le|qun PENG Yi|mei ZHANG Xin|hua et al |
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| Affiliation: | BAO Le|qun,PENG Yi|mei,ZHANG Xin|hua,et,al Department of multitreatment,Hubei Tumor Hospital,Wuhan 430079,China |
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| Abstract: | Objective To investigate the relationship between the microvessel density (MVD) and basic fibroblast growth factor(b|FGF) expression in human renal carcinoma. Methods the expression of b|FGF and MVD in 35 cases of renal carcinoma were examined retrospectively byimmunohistochemical staining. Results B|FGF and MVD expression were significantly higher in human renal cancer tissue than the normal tissue surrounding the tumor, and they were of statistic significance as to clinical stage or clinical grade.... |
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| Keywords: | Renal cell carcinoma Microvessel density Basic fibroblast growth factor Immunohistochemical staining |
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