颞叶孤立性纤维瘤1例并文献复习

目的探讨颞叶孤立性纤维瘤（solitory fibrous tumor,SFT）的临床病理特征。方法对1例罕见的发生于颞叶的孤立性纤维瘤进行组织学观察和免疫组化分析,并复习文献。结果镜检细胞致密区与疏松区交替性分布,瘤细胞呈梭形及短梭形,血管增多并明显胶原化,并见血管外皮瘤样结构,瘤细胞间含有粗细不等、形状不一的胶原纤维。部分区域细胞异型性明显,核分裂像多见,〉10/10HPF。免疫组化染色结果显示CD34、vimentin、Bcl-2及CD99弥漫阳性。手术切除后,随访18个月,每3个月复查磁共振成像（magnetic resonance imaging,MRI）,未见复发及转移。结论颞叶孤立性纤维瘤少见,组织学观察与免疫组化检测是确诊的关键。

Temporal Lobe Solitory Fibrous Tumor: a Case Report and Review of Literature

Objective To investigate the clinicopathological features of the solitary fibrous tumor(SFT) in the temporal lobe.Methods The histological observation and immunohistochemical analysis was performed on a case with SFT in the temporal lobe.The related literature was reviewed.Results The microscopical presence of spindle-shaped and short spindle-shaped cells arranged in fascicles that alternate hypocellular and hypercellular areas separated from each other by collagenous fibre.The number of vessels was increased obviously,and the hemangiopericytoma-like pattern was observed.There were collagenous fibres with varying shapes and thickness among the tumor cells.Some tumor cells exhibited nuclear pleomorphism and atypia,mostly with mitotic manifestations and >10/10HPF.The immunohistochemical staining indicated positive vimentin,CD34,Bcl-2 and CD99.The patients were followed-up for 18 months and accepted magnetic resonance imaging(MRI) examination every 3 months.No tumor recurrence and metastasis was observed.Conclusion Temporal lobe SFT is rare,and the histopathological observation and immunohistochemical testing are crucial for correct diagnosis.