| 大蒜素自微乳的制备与质量评价 |
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| 引用本文： | 徐云峰,刘清飞,陈曦,罗国安,王义明.大蒜素自微乳的制备与质量评价[J].中国新药杂志,2008,17(22):1940-1944. |
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| 作者姓名： | 徐云峰 刘清飞 陈曦 罗国安 王义明 |
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| 作者单位： | 1. 清华大学医学院,北京,100084;江西中医学院,南昌,330006
2. 清华大学医学院,北京,100084 |
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| 基金项目： | 国家自然科学基金
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清华大学裕元基金
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| 摘 要： | 目的:制备大蒜素(DATS)自微乳制剂,并评价其质量.方法:采用伪三元相图法,以聚氧乙烯氢化蓖麻油RH-40为表面活性剂,无水乙醇为助表面活性剂,油酸为油相,绘制该系统的相图,在此基础上制备DATS自微乳;建立HPLC法测定DATS自微乳中DATS的含量;对自微乳的外观性状、相对密度、黏度、pH值、电导率、形态、粒径及粒度分布、Zeta电位、含量、配伍和稳定性等进行研究.结果:DATS自微乳为无色澄明液体,稳定性良好,相对密度为0.840 g·mL-1,黏度为5.447 mPa·s,遇水形成O/W型微乳,稀释250倍后电镜下观察成圆球形,平均粒径26.4 nm,Zeta电位0.398 mV,pH值5.62,电导率为8.37μs·cm-1,3批制剂的含量分别为31.77,31.45,32.15 mg·mL-1.DATS自微乳与葡萄糖注射液、氯化钠注射液等配伍稳定.结论:DATS自微乳制备工艺简单,性质稳定,质量易控.
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| 关 键 词： | 大蒜素 自微乳 制备 质量评价 |
Preparation and quality evaluation of dially trisulfide self-microemulsifying drug delivery system |
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| XU Yun-feng,LIU Qing-fei,CHEN Xi,LUO Guo-an,WANG Yi-ming.Preparation and quality evaluation of dially trisulfide self-microemulsifying drug delivery system[J].Chinese Journal of New Drugs,2008,17(22):1940-1944. |
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| Authors: | XU Yun-feng LIU Qing-fei CHEN Xi LUO Guo-an WANG Yi-ming |
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| Institution: | XU Yun-feng1,2,LIU Qing-fei1,CHEN Xi1,LUO Guo-an1,WANG Yi-ming1(1 Institute of Biomedicine,Tsinghua University,Beijing 100084,China,2 Jiangxi University of TCM,Nanchang 330006,China) |
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| Abstract: | Objective:To prepare dially trisulfide(DATS) self-microemulsifying drug delivery system(SMEDDS) and evaluate its quality.Methods:Pseudo-ternary phase was used to evaluate the self-microemulsification existence area.The formulation and the preparation of DATS SMEDDS were studied.HPLC method was used to determine DATS SMEDDS.The appearance,density,viscosity,pH,electrical conductivity,morphology,particle size distribution,Zeta potential,contents,and stability of DATS SMEDDS were studied,respectively.Results:Th... |
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| Keywords: | dially trisulfide(DATS) self-microemulsifying drug delivery system(SMEDDS) preparation quality evaluation |
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