Pancreatic microcirculation in acute pancreatitis |
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Authors: | Makoto Sunamura Jun-ichiro Yamauchi Kazuhiko Shibuya Hang-Ming Chen Lianghao Ding Kazunori Takeda Masao Kobari and Seiki Matsuno |
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Institution: | (1) First Department of Surgery, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-77, Japan, JP |
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Abstract: | We present a review of the microvascular morphology of the pancreas and microstructure of the pancreatic lobule, and report
our experimental results of the investigation of pancreatic microcirculation following acute pancreatitis. Impairment of pancreatic
microcirculation in the early phase of acute pancreatitis may play a key role in the progression of this disease. Possible
contributory mechanisms include increased vascular permeability, reduced blood flow, leukocyte-endothelial cell interaction
and intravascular thrombus formation. Using an in-vivo microscope system and off-line computer analysis, we achieved direct
visualization and quantification of changes in microvascular permeability and leukocyte behavior in pancreas with acute pancreatitis.
Bradykinin and oxygen radicals have been demonstrated to be involved in the increase of vascular permeability in the early
stage of caerulein pancreatitis. Leukocyte adherence to the vessels in the pancreatic microcirculation is a secondary event
following permeability changes in acute pancreatitis. Leukocyte infiltration during exacerbation of acute pancreatitis is
mediated by leukocyte-endothelial cell interaction via leukocyte integrin CD11b/18.
Received for publication on Jan. 29, 1997; accepted on April 24, 1997 |
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Keywords: | : pancreatic microcirculation acute pancreatitis permeability leukocyte endothelial cell interaction vital microscopy |
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