The in vivo effects of unloading and compression on T1-Gd (dGEMRIC) relaxation times in healthy articular knee cartilage at 3.0 Tesla |
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Authors: | Marius E Mayerhoefer Goetz H Welsch Tallal C Mamisch Franz Kainberger Michael Weber Stefan Nemec Klaus M Friedrich Albert Dirisamer Siegfried Trattnig |
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Institution: | 1. Department of Radiology, MR Center, Medical University of Vienna, Lazarettgasse 14, 1090, Vienna, Austria 2. Department of Trauma Surgery, University of Erlangen, Krankenhausstrasse 12, 91054, Erlangen, Germany 3. Department of Orthopaedic Surgery, Inselspital, University Bern, Freiburgstrasse, 3010, Bern, Switzerland
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Abstract: | Purpose The purpose was to investigate the in vivo effects of unloading and compression on T1-Gd relaxation times in healthy articular knee cartilage. Materials and methods Ten volunteers were enrolled, and dGEMRIC images of their right knee joints were obtained using 3.0-T MR at three timepoints: directly following exercise (“baseline”), approximately 15 min after unloading (“unloading”) and during application of a compressive force (50% of the body weight) generated by a loading device via a footplate (“compression”). Results Our analysis of variance of pooled data from all cartilage zones demonstrated a significant mean T1-Gd decrease of 56.6 ms between baseline and compression (p?<?0.001), and a significant mean decrease of 42.1 ms between unloading and compression (p?<?0.001). No significant difference was found between baseline and unloading. Higher mean T1-Gd values were observed in the cartilage contact zone (central femoral and tibial zones; 698.3?±?162.2 ms) than in the non-contact zone (anterior and posterior femoral and tibial zones, and dorsal femoral zone; 662.9?±?149.3 ms; p?<?0.01). Conclusion T1-Gd times appear to be sensitive to mechanical cartilage stress, and thus, further studies are warranted that investigate the relationship between the biochemical load response and the biomechanical properties of articular cartilage. |
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