MicroRNA-34a is a potent tumor suppressor molecule <Emphasis Type="Italic">in vivo</Emphasis> in neuroblastoma |
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| Authors: | Amanda Tivnan Lorraine Tracey Patrick G Buckley Leah C Alcock Andrew M Davidoff Raymond L Stallings |
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| Institution: | (1) Department of Cancer Genetics, Royal College of Surgeons in Ireland, York House, York Street, Dublin 2, Ireland;(2) National Children’s Research Centre, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland;(3) Department of Surgery, St. Jude Children’s Research Hospital, 38105 Memphis, TN, USA;(4) Department of Surgery, University of Tennessee Health Science Center, 38105 Memphis, TN, USA |
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| Abstract: | Background Neuroblastoma is a paediatric cancer which originates from precursor cells of the sympathetic nervous system and accounts
for 15% of childhood cancer mortalities. With regards to the role of miRNAs in neuroblastoma, miR-34a, mapping to a chromosome
1p36 region that is commonly deleted, has been found to act as a tumor suppressor through targeting of numerous genes associated
with cell proliferation and apoptosis. |
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