S100A4蛋白在妇科恶性肿瘤中的研究进展

S100A4蛋白是钙结合蛋白家族成员之一,其通过对钙离子的调节及与靶蛋白的相互作用在体内发挥多种生物学作用,如参与细胞周期活动、细胞分化、肿瘤生长以及细胞外基质分泌活动等过程。近年大量研究表明,S100A4蛋白在多种肿瘤中呈现高表达且具有细胞和组织的分布特异性,并与肿瘤的浸润和转移密切相关,因而备受关注。就S100A4蛋白的分子生物学特点,在调节肿瘤细胞的转移方式和功能方面及其在妇科肿瘤中的作用做文献综述。

The Role of S100A4 Protein in Gynecological Carcinoma

S100A4 protein is a member of the calcium-binding protein family,which through the regulation of calcium and interaction with the target protein in the body,plays various biological functions,such as participating in the activities of the cell cycle,cell differentiation,tumor growth and the secretion of extracellular matrix activities in the process.In recent years,a large amount of studies indicate that S100A4 protein in a variety of tumors shows high expression and has a specific distribution of cells and tissues,and with tumor invasion and metastasis are closely related to the cause for concern.Here,we make a review of S100A4 for its molecular biological characteristics,the manners of regulating the metastasis of the tumor cells,and also its functions in gynecology tumors.