| EFFECTS OF CURCUMIN ON PROLIFERATION AND
APOPTOSIS IN ACUTE MYELOID LEUKEMIA CELLS HL-60 |
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| 作者姓名： | 吴裕丹 陈燕 陈文娟 喻东姣 李惠玉 |
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| 作者单位： | Insititute of Heamatology，Xie-he Hospital，Tongji Medical University，Wu ban 430022，China |
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| 基金项目： | the National Natural Science Foundation of China (No.39770934). |
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| 摘 要： | Curcuministhemajoringredientofextractsfromcurryfamilywidelyusedasayellowspiceandfoodadditive.Ithasavarietyofpharmacologicaleffectsincludinganti-inflammation,antioxidant,decreasingbloodlipid,enhancingphagocaryosisofmonocyte-macrophagesystemandregulatinghumanimmunityfunction.Ithasbeenshowntohaveanticarcinogenicpropertiesinanimalmodelsincludingcutaneous,gastrointestinaltractandbreastcancercausedbymanykindsofcarcinogenesisagents1].Invitrostudieshaveshownthatcurcuminselectivelyinhibitgrowthofsomep…
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| 收稿时间： | 20 September 2008 |
Effects of curcumin on proliferation and apoptosis in acute myeloid leukemia cells HL-60 |
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| Yu-dan Wu,Yan Chen,Wen-juan Chen,Dong-xiao Yu,Hui-yu Li.EFFECTS OF CURCUMIN ON PROLIFERATION AND
APOPTOSIS IN ACUTE MYELOID LEUKEMIA CELLS HL-60[J].Chinese Journal of Cancer Research,2000,12(2):96-98. |
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| Authors: | Yu-dan Wu Yan Chen Wen-juan Chen Dong-xiao Yu Hui-yu Li |
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| Institution: | (1) Institute of Heamatology, Xie-he Hospital, Tong-ji Medical University, No.575 Jie-Fang-Da-Dao Street, Han-kou District, 430032 Wuhan, China |
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| Abstract: | To investigate the curcumin killing leukemia cells in vitro,. Methods: The myeloid leukemic cell line HL-60 was studied by using cell culture, flow cytometrydetermining DNA content and TUNEL method measuring apoptotic cell percentage. Results: The data showed that curcumin selectively inhibited proliferation of acute myeloid leukemia (AML) HL-60 cell lines in a dose- and time-dependent manner. The growth inhibition rate was gradually increased and reached the peak at concentration of 25 m mol/L curcumin at 24h. The sub-G1 peak appeared after 12h treatment and was increased to 34.4% at 24h. The TUNEL method further certified that apoptotic cells reached 41% at the same phase. Conclusion: curcumin possesses obvious potent of anti-leukemia cell proliferation, which is contributed to the induction of HL-60 cells apoptosis. The concentration and action time of curcumin in vitro provide some reference for clinical use. |
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| Keywords: | curcumin proliferation apoptosis HL-60 |
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