地尔硫■控释片与戊四硝酯片对老年冠心病心绞痛与收缩时间间期的疗效比较

目的：比较盐酸地尔硫控释片（下简称地片）与戊四硝酯（下简称硝片）治疗老年冠心病心绞痛的疗效及对收缩时间间期（ＳＴＩ）的影响。方法：冠心病心绞痛病人４５例（男性２９例，女性１６例；年龄６４±ｓ４ａ）以随机、双盲、交叉对照法分别先后采用地片３０～９０ｍｇ，ｐｏ，ｔｉｄ，加外观似硝片的安慰剂（淀粉）１～３片，ｐｏ，ｔｉｄ，共４ｗｋ，为治疗组；或以硝片１０～３０ｍｇ，ｐｏ，ｔｉｄ，加外观似地片的安慰剂１～３片，ｐｏ，ｔｉｄ，共４ｗｋ，为对照组。２组于４ｗｋ疗程结束时，各给２种安慰剂１ｗｋ，待体内药物排尽然后２组交叉服药４ｗｋ。结果：地片组与硝片组比较，心绞痛症状疗效分别为９６％对４２％（Ｐ＜０．０１）；心电图疗效分别为４４％对２９％（Ｐ＞０．０５）；治疗组有显著降低高血压病人的舒张压及ＰＥＰ／ＬＶＥＴ比值的作用。结论：地片对心绞痛症状疗效、对原有高血压和ＳＴＩ不正常者疗效优于硝片。

Comparison of diltiazem hydrochloride controlled release tablet and pentaerithrityl tetranitrate tablet on angina pectoris and systolic time intervals in elderly coronary disease

AIM: To campare the diltiazem hydrochloride (Dil) and pentaerithrityl tetranitrate (PT) on coronary disease with angina pectoris and systolic time intervals (STI) in elderly. METHODS: Coronary disease with angina pectoris 45 patients (M 29, F 16; age 64±s 4 a) by randomized, double-blind and cross-over tests with Dil 30-90 mg(30 mg/Tab), po, tid, and placebo (starch) 1-3 tablets, po, tid×4 wk. PT 10-30 mg(10 mg/Tab) po, tid, and placebo (starch) 1-3 tablets, po, tid×4 wk. Then cross-over ×4 wk. RESULTS: The clinical symptom and ECG effective rate were 96% vs 44%(P<0.01), and 44% vs 29%(P>0.05), respectively Dil vs PT. Dil reduced blood pressure in patients with hypertension, especially for diastolic pressure (P<0.05), in addition, Del reduced PEP/LVET in coexist hypertension patients with raised PEP/LVET. CONCLUSION: Effect of Dil is better than PT. 1Jinshan County Central Hospital, Shanghai 201500