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美施康定对癌症疼痛的镇痛效果
引用本文:李平,庄承海,廖倚萍,郑坚. 美施康定对癌症疼痛的镇痛效果[J]. 中国药物依赖性杂志, 1999, 8(2): 135-137
作者姓名:李平  庄承海  廖倚萍  郑坚
作者单位:暨南大学医学院附一院肿瘤科,广州,510630
摘    要:本组54例重度癌痛晚期病人,给予口服美施康定30-90mg,每12h一次治疗,有效率96.3%(52/54),完全缓解率达87.0%(47/54)。治疗中同时应用化疗及放疗,从病因上消除癌症所致的疼痛,部分病人因疼痛缓解而停用美施康定。应用美施康定其主要的副作用为便秘、恶心、呕吐、嗜睡等,治疗剂量未出现呼吸抑制及成瘾性发生。美施康定对骨痛、内脏痛、软组织浸润痛的镇痛效果较好,对神经痛效果欠佳,对这类疼痛应联合使用三环类药物,抗惊厥类及皮质类固醇等治疗。美施康定口服给药后,其起效时间及作用时间存在着个体差异,应遵循个体化原则增加剂量及用药间隙时间,以达到最理想的镇痛效果

关 键 词:癌痛;美施康定;镇痛剂

MANAGING CANCER PAIN WITH MORPHINE SULPHATE CONTROLLED - RELEASE TABLETS
Li Ping,Zhuang Chenghai,Liao Yiping,Zheng Jian. MANAGING CANCER PAIN WITH MORPHINE SULPHATE CONTROLLED - RELEASE TABLETS[J]. Chinese Journal of Drug Dependence, 1999, 8(2): 135-137
Authors:Li Ping  Zhuang Chenghai  Liao Yiping  Zheng Jian
Abstract:Fifty-four patients with severe cancer pain were treated with morphine sulphate controlled-release tablets(MS Contin), 30-90 mg each time,po, twice daily. The total response rate and complete remission rate were 96.3%(52/54) and 87%(47/54) respectively. Chemotherapy and radiotherapy were given stimutaneously. Some of the patients whose pain released stopped using MS Contin. The main clinical side-effects were constipation, nausea, vomiting, somnolence etc. No opium drug addiction and respiratory restraint were found within treatment dosage.
Keywords:cancer pain  MS Contin  analgesics
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