美施康定对癌症疼痛的镇痛效果

本组５４例重度癌痛晚期病人，给予口服美施康定３０－９０ｍｇ，每１２ｈ一次治疗，有效率９６．３％（５２／５４），完全缓解率达８７．０％（４７／５４）。治疗中同时应用化疗及放疗，从病因上消除癌症所致的疼痛，部分病人因疼痛缓解而停用美施康定。应用美施康定其主要的副作用为便秘、恶心、呕吐、嗜睡等，治疗剂量未出现呼吸抑制及成瘾性发生。美施康定对骨痛、内脏痛、软组织浸润痛的镇痛效果较好，对神经痛效果欠佳，对这类疼痛应联合使用三环类药物，抗惊厥类及皮质类固醇等治疗。美施康定口服给药后，其起效时间及作用时间存在着个体差异，应遵循个体化原则增加剂量及用药间隙时间，以达到最理想的镇痛效果

MANAGING CANCER PAIN WITH MORPHINE SULPHATE CONTROLLED - RELEASE TABLETS

Fifty-four patients with severe cancer pain were treated with morphine sulphate controlled-release tablets(MS Contin), 30-90 mg each time,po, twice daily. The total response rate and complete remission rate were 96.3%(52/54) and 87%(47/54) respectively. Chemotherapy and radiotherapy were given stimutaneously. Some of the patients whose pain released stopped using MS Contin. The main clinical side-effects were constipation, nausea, vomiting, somnolence etc. No opium drug addiction and respiratory restraint were found within treatment dosage.