Successive transformation of chronic myelomonocytic leukaemia into acute myeloblastic then lymphoblastic leukaemia, both with minor-bcr rearrangement |
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| Authors: | Marie Michè le, DAUTEL ,Sylvie,FRANÇ OIS ,Marie-FranÇ oise, BERTHEAS ,Laurence,BARANGER ,Jacques,GARDAIS ,Marc,BOASSON ,Norbert,IFRAH & Odile,BLANCHET |
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| Affiliation: | Laboratoire d'Hématologie, CDTS Angers,;Laboratoire d'Hématologie, CHU Saint-Etienne,;Laboratoire de Cytogénétique, CHU Angers,;Service des Maladies du Sang CHU, Angers, et;Laboratoire d'Hématologie Moléculaire, CHU Angers, France |
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| Abstract: | We report a case of chronic myelomonocytic leukaemia (CMML), which transformed first into acute myeloblastic leukaemia (AML) and then into acute lymphoblastic leukaemia (ALL). In the AML and ALL phases, chromosome analysis showed a classic Philadelphia chromosome (Ph) t(9;22)(q34;q11). Molecular studies showed breakpoint cluster region rearrangement between exons e1 and a2 compatible with a p190bcr/abl breakpoint as observed in Ph-positive lymphoblastic acute leukaemia. The minor (m-bcr) rearrangement was also detected during complete remission.
This observation supports a multistep pathogenesis of leukaemias, and that the p190bcr/abl breakpoint may influence the course of the disease. |
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| Keywords: | chronic myelomonocytic leukaemia acute myeloblastic leukaemia acute lymphoblastic leukaemia Philadelphia chromosome p190bcr/abl protein |
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