| 去势小鼠自体冷冻卵巢移植后海马神经元超微结构变化 |
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| 引用本文： | 赵承军,孔斌,张炎,崔岫,朱万平,黑常春. 去势小鼠自体冷冻卵巢移植后海马神经元超微结构变化[J]. 宁夏医科大学学报, 2008, 30(1): 4-6 |
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| 作者姓名： | 赵承军 孔斌 张炎 崔岫 朱万平 黑常春 |
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| 作者单位： | 宁夏医学院基础学院组织学与胚胎学教研室,银川,750004;宁夏医学院中心实验室,银川,750004 |
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| 基金项目： | 宁夏教育厅和宁夏医学院项目资助 |
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| 摘 要： | 目的观察去势小鼠卵巢移植对大脑海马神经元超微结构变化的影响,探讨卵巢分泌激素对中枢神经系统的作用。方法将去势雌性BALB/C小鼠随机分为移植组、去势对照组和空白对照组,每组各10只。移植组于去势后2周行自体冷冻卵巢解冻移植,移植组于移植2周后、去势对照组和空白对照组于4周后取大脑海马部位观察神经元行形态学变化。结果移植组小鼠大脑神经元超微结构与正常对照组相同,形态及结构完整正常;神经元突触密度较去势对照组增高(P<0.01),而去势对照组小鼠神经元结构欠完整,突触密度也降低。结论去势小鼠行卵巢移植可增加海马神经元突触数,保护神经元的形态结构和功能。
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| 关 键 词： | 去势 卵巢移植 海马神经元 小鼠 |
| 文章编号： | 1005-8486（2008）01-0004-03 |
| 收稿时间： | 2007-06-13 |
| 修稿时间： | 2007-06-13 |
Observation on Ultrastructure of Hippocamp Neuron of Self-freezing Ovary Transplanting in Castrate Mouse |
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| ZHAO Cheng-jun , KONG Bin, ZHANG Yan, et al. Observation on Ultrastructure of Hippocamp Neuron of Self-freezing Ovary Transplanting in Castrate Mouse[J]. Journal of Ningxia Medical College, 2008, 30(1): 4-6 |
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| Authors: | ZHAO Cheng-jun KONG Bin ZHANG Yan et al |
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| Abstract: | Objective To observe the ultrastructure of hippocamp neuron of castrate mouse in transplanting,and to discuss the effect of estrogen on central nervous system.Methods 30 mices were divided randomly into 3 groups.Transplanting group performed transplantation after 2 weeks castrated.After 2 weeks transplanted,control group and castrate control group got hippocamp observed neuron morphology hanging.Results The morphous and structure of neuron ultrastructure in transplanting group was normal;synapes density of transplanting groupwas higher than that of control group(P<0.001).Conclusion Ovary transplanting of castrate mouse could add synapse number and protect morphous structure and function of neuron. |
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| Keywords: | castrate ovary transplantation hippocamp neuron mouse |
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