| 慢性肾脏病患者血清内脏脂肪素水平升高及其与颈动脉粥样硬化的关系 |
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| 引用本文： | 唐湘玲,陈梦颖,张卫茹. 慢性肾脏病患者血清内脏脂肪素水平升高及其与颈动脉粥样硬化的关系[J]. 中南大学学报(医学版), 2013, 38(6): 553-559 |
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| 作者姓名： | 唐湘玲 陈梦颖 张卫茹 |
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| 作者单位： | 中南大学湘雅医院风湿科,长沙,410078 |
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| 基金项目： | the,Natural,Science,Foundation,of,Hunan,Province,P.R.China(项目编号：09sk3197,12JJ5058,2013SK3017) |
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| 摘 要： | 目的:观察慢性肾脏病(chronic kidney disease,CKD)患者血清内脏脂肪素(visfatin)水平,探讨其与颈动脉粥样硬化(atherosclerosis,AS)的关系.方法:入选CKD患者180例(非透析治疗102例,血液透析治疗78例)和年龄匹配的健康对照42例.ELISA检测血清visfatin,炎症指标IL-6和高敏C反应蛋白(high sensitive C-reactive proteins,hsCRP)水平;高分辨超声技术检测颈动脉内膜—中层厚度(intima media thickness,IMT),切面内膜中层(c IMT)面积及粥样硬化斑块.结果:CKD患者血清visfatin,IL-6,hsCRP水平均明显高于健康对照组(P＜0.01).透析CKD患者血清visfatin,IL-6,hsCRP水平均明显高于非透析CKD患者(P＜0.05).CKD患者血清visfatin水平与内生肌酐清除率(Ccr)呈负相关(r=-0.415,P＜0.05).颈动脉有斑块的CKD患者血清visfatin[(34.22±7.96)ng/mL)]明显高于无斑块者[(28.24±6.18) ng/mL,P＜0.05].直线相关分析显示CKD患者血清visfatin水平与IL-6(r=0.548,P＜0.001),hsCRP(r=0.430,P＜0.001),IMT(r=0.462,P＜0.05)及c IMT面积(r=0.411,P＜0.05)呈正相关.经Ccr、年龄、性别及其他与AS相关因素校正后,多因素逐步回归分析结果显示血清visftin是颈动脉IMT(β=0.433,P＜0.01)和c IMT面积(β=0.412,P＜0.01)的独立危险因素.结论:血清visfatin水平随肾功能减退而增高,可能成为CKD患者颈动脉粥样硬化的风险因子.
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| 关 键 词： | 慢性肾脏病 内脏脂肪素 动脉粥样硬化 炎症 |
Association between elevated visfatin and carotid atherosclerosis in patients with chronic kidney disease |
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| TANG Xiangling , CHEN Mengying , ZHANG Weiru. Association between elevated visfatin and carotid atherosclerosis in patients with chronic kidney disease[J]. Journal of Central South University. Medical sciences, 2013, 38(6): 553-559 |
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| Authors: | TANG Xiangling CHEN Mengying ZHANG Weiru |
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| Abstract: | |
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| Keywords: | chronic kidney disease visfatin atherosclerosis inflammation |
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